Protective effects of thymoquinone on D-galactose and aluminum chloride induced neurotoxicity in rats: biochemical, histological and behavioral changes

Neurological Research
Yasmin S AbulfadlOsama A Badary

Abstract

Thymoquinone (TQ), the main active ingredient in Nigella sativa oil, exhibits various bioactivities. This study aimed to investigate the effect of TQ on neurobehavioral and neuropathological alterations induced by aluminum trichloride (AlCl3) and D-galactose (D-gal)-in male rats and to explore the related mechanisms. D-gal (60 mg/kg day) and AlCl3 (10 mg/kg day) were given intraperitoneally (i.p.) once daily for 42 days and after 4 weeks TQ was concomitantly administered intragastrically (i.g.) (20 mg/kg/day) once daily for 14 days. Then, memory function was evaluated by Morris water maze test (MWM). Superoxide dismutase (SOD), Total antioxidant capacity (TAC), Acetylcholinesterase (AChE) activities, and malondialdehyde (MDA), nitric oxide (NO), brain-derived neurotrophic factor (BDNF), and B-cell lymphoma-2 (Bcl-2) levels in whole brain were assessed with the biochemical technique. Tumor necrosis factor-alpha (TNF-α) and Acetylcholine (ACh) were also assessed using an immunohistochemical technique. Administration of TQ significantly improved cognition. In addition, TQ significantly increased SOD and TAC and decreased AChE activities. It also decreased MDA and NO levels as well as TNF-α immunoreactivity and increased BDNF and B...Continue Reading

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Citations

Jun 9, 2018·International Journal of Molecular Sciences·Yongfeng ZhangDi Wang
Jun 20, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Ebrahim M YimerFarooq Anwar
Sep 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Li FengHuaide Xu
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Samaila Musa ChiromaMohamad Aris Mohd Moklas
Mar 23, 2021·Food Science & Nutrition·Masood Sadiq ButtZaffar Mehmood
May 13, 2021·Drug Design, Development and Therapy·Osama A BadaryRajiv Tikamdas
Jul 3, 2021·International Journal of Molecular Sciences·Ali H El-FarAhmed E Noreldin
Jun 17, 2021·World Journal of Clinical Oncology·Maya M MoubarakHala Gali-Muhtasib

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