Protective Effects of Tormentic Acid, a Major Component of Suspension Cultures of Eriobotrya japonica Cells, on Acetaminophen-Induced Hepatotoxicity in Mice

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Wen-Ping JiangGuan-Jhong Huang

Abstract

An acetaminophen (APAP) overdose can cause hepatotoxicity and lead to fatal liver damage. The hepatoprotective effects of tormentic acid (TA) on acetaminophen (APAP)-induced liver damage were investigated in mice. TA was intraperitoneally (i.p.) administered for six days prior to APAP administration. Pretreatment with TA prevented the elevation of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (T-Bil), total cholesterol (TC), triacylglycerol (TG), and liver lipid peroxide levels in APAP-treated mice and markedly reduced APAP-induced histological alterations in liver tissues. Additionally, TA attenuated the APAP-induced production of nitric oxide (NO), reactive oxygen species (ROS), tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β), and IL-6. Furthermore, the Western blot analysis showed that TA blocked the protein expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), as well as the inhibition of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs) activation in APAP-injured liver tissues. TA also retained the superoxidase dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) in the liver. These results suggest that the h...Continue Reading

References

Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J S BeckmanB A Freeman
Apr 1, 1983·The Journal of Clinical Investigation·B H LauterburgJ R Mitchell
Mar 21, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C R GardnerD L Laskin
Feb 7, 2002·Phytochemistry·Shoko TaniguchiTakashi Yoshida
Dec 19, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hartmut Jaeschke
Sep 19, 2003·Biochemical and Biophysical Research Communications·Laura P JamesJack A Hinson
Nov 20, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Laura P JamesJack A Hinson
Jan 28, 2004·Bioscience, Biotechnology, and Biochemistry·Norihiro BannoHoyoku Nishino
Jul 5, 2005·Journal of Ethnopharmacology·Jie Liu
Oct 6, 2005·Biological & Pharmaceutical Bulletin·Norihiro BannoHoyoku Nishino
Apr 14, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Guoli DaiYu-Jui Yvonne Wan
Aug 18, 2006·The Journal of Biological Chemistry·Nathalie CarayolCun-Yu Wang
Dec 1, 2006·Cardiovascular Drugs and Therapy·Qin ZhangQiang Wang
Apr 14, 2007·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Y HuangY-Y Wang
Sep 25, 2007·Bioorganic & Medicinal Chemistry·Gleice da Graça RochaCerli Rocha Gattass
Dec 7, 2007·Planta medica·Yongli ZhangYongxian Cheng
Jul 1, 2008·Biochemical and Biophysical Research Communications·Mohammed BourdiLance R Pohl
May 26, 2009·European Journal of Pharmacology·Anelize S FogoAlexandre H Campos
Dec 19, 2009·Handbook of Experimental Pharmacology·Jack A HinsonLaura P James
Jul 27, 2010·Journal of Bioscience and Bioengineering·Hui-ya HoJin-bin Wu
Mar 5, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chun-Ching ShihHui-Ya Ho
Apr 16, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jung-Ran NohChul-Ho Lee
Jul 11, 2014·World Journal of Gastroenterology : WJG·Halina Cichoż-Lach, Agata Michalak
Jul 30, 2014·Medicine·Cheng-Maw HoRey-Heng Hu
Dec 31, 2014·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Mostafa M El-ShafeyAmr D Mariee
Jun 23, 2015·International Journal of Molecular Medicine·Giou-Teng YiangChyou-Wei Wei
Jul 1, 2015·African Health Sciences·Kammoun MaherBezzine Sofiane
Jan 23, 2016·Oxidative Medicine and Cellular Longevity·Martha Lucinda Contreras-Zentella, Rolando Hernández-Muñoz
Jan 26, 2016·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Qi GuoPengyuan Zheng
Feb 26, 2016·Cellular & Molecular Immunology·Cynthia Ju, Frank Tacke

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Citations

Sep 23, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kun-Chang WuYuan-Shiun Chang
Dec 6, 2018·Nutrition Research and Practice·Nawal El MenyiyBadiaa Lyoussi
Jan 19, 2021·Journal of Ethnopharmacology·Wen ZhangBangjiang Fang
Dec 4, 2019·Microbial Pathogenesis·Chinmoy GhoshSurajit Bhattacharjee
Apr 20, 2021·Natural Product Research·Ayesheh EnayatiNarguess Yassa
Jun 5, 2021·Environmental Science and Pollution Research International·Weishun TianByung-Yong Park
Jun 8, 2021·Frontiers in Pharmacology·Valentina EcheverriaCristhian Mendoza
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marta OlechNatalia Nowacka-Jechalke
Mar 1, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hongli GuoJing Xu
Sep 22, 2020·Mini Reviews in Medicinal Chemistry·Bruna da Silva SouzaJefferson Soares de Oliveira

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Methods Mentioned

BETA
MDA
enzyme linked immunosorbent assay
electrophoresis

Software Mentioned

Kodak Molecular Imaging

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