PMID: 9764721Oct 9, 1998Paper

Protective effects of valsartan and benazeprilat in salt-loaded stroke-prone spontaneously hypertensive rats

Clinical and Experimental Hypertension : CHE
R L WebbP Sahota

Abstract

These experiments examined the effectiveness of chronic blockade of the renin angiotensin system with either valsartan or benazeprilat on survival, blood pressure and end-organ damage in salt-loaded stroke-prone SHR. Valsartan or benazeprilat given continuously by subcutaneous osmotic minipump beginning at 10.5 weeks of age lowered blood pressure, as determined by radiotelemetry, prevented proteinuria, prolonged survival and decreased the severity of histopathological changes in the heart and kidney. These results indicate that angiotensin receptor blockade affords a similar degree of protection as inhibition of angiotensin converting enzyme in salt-loaded stroke-prone SHR. Furthermore, our results are consistent with a primary contribution of angiotensin II to the maintenance of blood pressure and support a principal role for angiotensin II-dependent mechanisms in the development of end-organ damage in the salt-loaded stroke-prone SHR.

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Citations

Jul 12, 2001·Advances in Therapy·L M Ruilope
May 3, 2000·Kidney International·M W Taal, B M Brenner
Feb 3, 2015·European Journal of Pharmacology·Jouko LevijokiAntti Haapalinna
Apr 23, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·M de GasparoJ P Clozel
Apr 21, 2001·Cardiovascular Drug Reviews·M E CooperM de Gasparo

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