Protective effects of vitamin E against reproductive toxicity induced by di(2-ethylhexyl) phthalate via PPAR-dependent mechanisms

Toxicology Mechanisms and Methods
Yangcai WangGuang-hui Wei

Abstract

To investigate the protective/ameliorative effects of vitamin E on di-2-(ethylhexyl) phthalate (DEHP)-induced reproductive toxicity, particularly in testicular toxicity in male rats, emphasizing peroxisome proliferator-activated receptor (PPAR)-dependent mechanism. Sprague-Dawley females were exposed by oral route to DEHP alone or associated with vitamin E from gestation day (GD) 12.5 to postnatal day (PND) 3 according to the following treatment regimens: vehicle control (corn oil), vitamin E (200 mg/kg)+corn oil, DEHP (500 mg/kg)+corn oil, and DEHP (500 mg/kg)+vitamin E (200 mg/kg)+corn oil. Variables including litter size, sex ratio, pup weight, post-implantation losses, and the number of viable pups were also assessed. Three male pups per litter were randomly selected and necropsied to measure paired testes weight, apoptosis, and gene expression on PND 3. To evaluate the long-term protective effects of vitamin E, three randomly selected males were necropsied to measure testis histology on PND 70. Supplementation of vitamin E (200 mg/kg) reduced malformations, increased testes weight and prevented the maternal bodyweight loss induced by DEHP. Litter size, sex ratio, and number of viable pups were unaffected, but vitamin E co-...Continue Reading

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Citations

Aug 28, 2020·Journal of Cosmetic Dermatology·Fatin N M NordinChe Wan Jasimah Wan Mohamed Radzi
Jan 20, 2019·Environmental Science and Pollution Research International·Ines AmaraSalwa Abid-Essefi
May 31, 2018·Journal of Toxicology and Environmental Health. Part a·Seul Min ChoiByung-Mu Lee
Jul 8, 2019·Environmental Health and Preventive Medicine·Yuki ItoTamie Nakajima
Jun 6, 2020·Cell Stress & Chaperones·Ines AmaraSalwa Abid-Essefi
Oct 13, 2020·Reproductive Toxicology·Hirokatsu SaitoKentaro Tanemura
May 1, 2021·Antioxidants·Stefano LorenzettiInga C Teller
May 24, 2021·Environmental Science and Pollution Research International·Hamidreza Mohammadi, Sorour Ashari

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