PMID: 7031210Dec 1, 1981Paper

Protective efficacy of a modified immune serum globulin in experimental group B streptococcal infection

The Journal of Pediatrics
J I SantosH R Hill

Abstract

In spite of aggressive antimicrobial therapy and extensive support measures, the mortality rate in early-onset group B streptococcal infection continues to be exceedingly high. In previous studies, we have demonstrated that passive immunotherapy with fresh whole blood containing opsonic antibody-improved survival in human neonates with group B disease. Transfusion of whole blood, plasma, or other blood products has a number of drawbacks, however. In the present study, we have evaluated immune serum globulin and a preparation of ISG modified for intravenous use for levels of type-specific antibody, opsonic activity, and protective efficacy against type Ia, II, and III group B streptococci. Type-specific antibody was detected in most of the preparations tested. In general, the level in MISG was less than that in the comparison ISG lot. Opsonic activity was also detected in these preparations against the more antibody-sensitive group B strains but was not present for opsonin resistant strains of type Ia, II, and III. Both ISG and MISG provided protection in neonatal rats infected with group B streptococci; in most cases MISG was more efficacious than the ISG from which it was made. These studies suggest that passive immunotherapy ...Continue Reading

References

Dec 1, 1976·The Journal of Clinical Investigation·V G HemmingH R Hill
Nov 1, 1977·The Journal of Infectious Diseases·P B Stewardson-KriegerS P Gotoff
Mar 25, 1978·Lancet·A O ShigeokaH R Hill
Jan 1, 1979·Journal of Immunological Methods·C D AllredH R Hill
Jun 1, 1966·The Journal of Hygiene·R C Lancefield, E H Freimer
Mar 31, 1934·The Journal of Experimental Medicine·R C Lancefield

❮ Previous
Next ❯

Citations

Feb 1, 1994·Acta Paediatrica Japonica; Overseas Edition·K Iguchi, S Inoue
Jun 1, 1983·Current Problems in Pediatrics·K L CatesM Ballow
Jan 1, 1992·Clinical Immunology and Immunopathology·H R HillH V Raff
Apr 25, 2006·Current Problems in Pediatric and Adolescent Health Care·David B LewisE Richard Stiehm
Jun 1, 1988·The Journal of Pediatrics·B DashefskyM Green
Aug 15, 1983·American Journal of Obstetrics and Gynecology·J W LarsenJ L Sever
Jan 1, 1989·Vox Sanguinis·L E WeismanC C Peck
Oct 23, 2002·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·S PatoleS Jog
Jun 11, 1983·The Medical Journal of Australia·G L Gilbert, S M Garland
Jun 1, 1993·Infection and Immunity·S K HollingsheadS M Michalek

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.