Protective efficacy of mouse serum to the N-propionyl derivative of meningococcal group B polysaccharide

Microbial Pathogenesis
F E AshtonH J Jennings

Abstract

The protective properties of antibodies induced by immunization of mice with a conjugate of tetanus toxoid and the N-propionyl derivative of group B meningococcal polysaccharide (N-Pr-GBMP-TT) have been investigated. Mice immunized with the conjugate produced antibodies which were bactericidal for Neisseria meningitidis strains B:2b:P1.Ham and B:15:P1.16. Passive protection studies indicated that the conjugate serum completely eliminated or reduced considerably levels of bacteremia by the same strains in mice. There was no bactericidal activity or passive protection against a strain of N. meningitidis C:2b:P1.2. Following absorption of the conjugate serum with GBMP the non-absorbed antibody, directed to N-Pr-GBMP, was bactericidal and protected mice against bacteremia with group B meningococci. Thus N-Pr-GBMP antibodies which do not bind to the GBMP are protective in vitro and in vivo.

References

Nov 1, 1972·The Journal of Infectious Diseases·F A WyleJ P Lowenthal
Jan 1, 1983·Reviews of Infectious Diseases·H Peltola
Jun 1, 1963·Journal of Bacteriology·D S KELLOGGD I PIRKLE

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Citations

Dec 12, 2001·Vaccine·S L Morley, A J Pollard
Apr 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Hilde-Kari GuttormsenDennis L Kasper
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Simona GalloriniAndreas Wack
Jan 5, 2006·The Journal of Experimental Medicine·Concetta BeninatiGiuseppe Teti
May 4, 2002·Lancet·Luis JódarDan M Granoff
Jan 25, 2011·Microbial Biotechnology·Ulrich Vogel, Heike Claus
Dec 2, 2005·Expert Opinion on Biological Therapy·Kirsten P Perrett, Andrew J Pollard
Apr 4, 2017·Pathogens and Disease·Myron Christodoulides, John Heckels
Mar 3, 2018·Vaccines·Pumtiwitt C McCarthyLaleh Sheikhi Moghaddam
Jun 14, 2014·Nature Reviews. Immunology·Ennio De Gregorio, Rino Rappuoli
Jun 3, 2009·Expert Review of Vaccines·Susan LewisAndrew J Pollard
Nov 3, 2006·Clinical and Vaccine Immunology : CVI·Samuel MooreFrancis Michon
May 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gregory R MoeBecca A Flitter
Oct 1, 1994·Clinical Microbiology Reviews·J Diaz Romero, I M Outschoorn
Jul 16, 2013·The Journal of Organic Chemistry·Guofeng GuB Mario Pinto

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