journal cover

Protective epitopes of the Plasmodium falciparum SERA5 malaria vaccine reside in intrinsically unstructured N-terminal repetitive sequences

PloS One

Jun 3, 2014

Masanori YagiToshihiro Horii

Abstract

The malaria vaccine candidate antigen, SE36, is based on the N-terminal 47 kDa domain of Plasmodium falciparum serine repeat antigen 5 (SERA5). In epidemiological studies, we have previously shown the inhibitory effects of SE36 specific antibodies on in vitro parasite growth and the neg...read more

Mentioned in this Paper

Muscle Rigidity
Immune Response
Flow Cytometry
Tryptophan
Repetitive Region
Merozoites
Genus Saimiri
Carboxy-Terminal Amino Acid
Immunologic Adjuvants
Antigens, CD16
Paper Details
References
  • References36
  • Citations9
1234

Similar Papers Found In These Feeds

Parasite Host Response

The parasite host response refers to the process by which the host organism responds to and interacts with the parasite it encounters. Discover the latest research on this topic in this feed.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Intrinsically Disordered Proteins

Intrinsically disordered proteins exhibit biological activity even though they lack a well-defined 3D structure in solution. Here is the latest research on their role in cells.

Plasmodium Vivax Malaria

Malaria

Malaria is a mosquito-borne infectious disease that affects humans and other animals. Malaria causes symptoms that typically include fever, tiredness, vomiting, and headaches. Discover the latest research on malaria here,

Plasmodium Falciparum

Malaria remains a major cause of morbidity and mortality in the tropics, with the parasite Plasmodium falciparum responsible for the majority of the disease burden. Discover the latest research on Plasmodium falciparum.

Immunomodulating Agents

Immunomodulating agents are substances that stimulate or suppresse the immune system and may help the body combat againsts cancer, infection, or other diseases. Discover the latest research on immunomodulating agents here.

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Plasmodium Falciparum Drug Resistance

Malaria Vaccines

Research for development of a malaria vaccine is currently underway to find an effective modality to control and eliminate the transmission of malaria. To date, no vaccine has been found to be efficacious in fighting against malaria. Here is the latest research on malaria vaccines.

Parasite Genetics

Parasite genetics is the study of the genetic material of parasites. Here is the latest research on parasite genetics.

Corticobasal Degeneration

Corticobasal Degeneration (CBD)is a rare, neurodegenerative disease of the cerebral cortex and the basal ganglia, characterized by movement disorders. Discover the latest research on CBD here.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Lymphopenia

Lymphopenia has been associated with autoimmune pathology and it has been suggested that lymphopenia-induced proliferation of naive T cells may be responsible for the development of immune pathology. Here is the latest research.


© 2020 Meta ULC. All rights reserved

Protective epitopes of the Plasmodium falciparum SERA5 malaria vaccine reside in intrinsically unstructured N-terminal repetitive sequences

PloS One

Jun 3, 2014

Masanori YagiToshihiro Horii

PMID: 24886718

DOI: 10.1371/journal.pone.0098460

Abstract

The malaria vaccine candidate antigen, SE36, is based on the N-terminal 47 kDa domain of Plasmodium falciparum serine repeat antigen 5 (SERA5). In epidemiological studies, we have previously shown the inhibitory effects of SE36 specific antibodies on in vitro parasite growth and the neg...read more

Mentioned in this Paper

Muscle Rigidity
Immune Response
Flow Cytometry
Tryptophan
Repetitive Region
Merozoites
Genus Saimiri
Carboxy-Terminal Amino Acid
Immunologic Adjuvants
Antigens, CD16

Similar Papers Found In These Feeds

Related Papers

Paper Details
References
  • References36
  • Citations9
1234
/papers/protective-epitopes-of-the-plasmodium-falciparum/24886718