Protective Factors in the Intestinal Microbiome Against Clostridium difficile Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation

The Journal of Infectious Diseases
Yeon Joo LeeYing Taur

Abstract

Clostridium difficile infection (CDI) is a frequent complication in recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT), who receive intensive treatments that significantly disrupt the intestinal microbiota. In this study, we examined the microbiota composition of allo-HSCT recipients to identify bacterial colonizers that confer protection against CDI after engraftment. Feces collected from adult recipients allo-HSCT at engraftment were analyzed; 16S ribosomal RNA genes were sequenced and analyzed from each sample. Bacterial taxa with protective effects against development of CDI were identified by means of linear discriminant analysis effect size analysis and then further assessed with clinical predictors of CDI using survival analysis. A total of 234 allo-HSCT recipients were studied; postengraftment CDI developed in 53 (22.6%). Within the composition of the microbiota, the presence of 3 distinct bacterial taxa was correlated with protection against CDI: Bacteroidetes, Lachnospiraceae, and Ruminococcaceae. Colonization with these groups at engraftment was associated with a 60% lower risk of CDI, independent of clinical factors. Colonization with these 3 bacterial groups is associated with a lower risk...Continue Reading

References

Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Oct 1, 1994·International Journal of Systematic Bacteriology·M D CollinsJ A Farrow
Mar 29, 2003·Science·Jian XuJeffrey I Gordon
Jan 18, 2008·The Journal of Infectious Diseases·Ju Young ChangVincent B Young
Jan 30, 2010·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Sharon LeungBrian P Currie
Oct 27, 2010·Clinical Transplantation·Teena ChopraGeorge J Alangaden
Jun 28, 2011·Genome Biology·Nicola SegataCurtis Huttenhower
Mar 6, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Lise WillemsRégis Peffault de Latour
Mar 14, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Carolyn D AlonsoKieren A Marr
Jun 22, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ying TaurEric G Pamer
Jul 7, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Fernanda C LessaL Clifford McDonald
Jan 18, 2013·The New England Journal of Medicine·Els van NoodJosbert J Keller
Oct 8, 2013·Nature Reviews. Immunology·Charlie G Buffie, Eric G Pamer
Dec 10, 2013·Nucleic Acids Research·Tatiana TatusovaIgor Tolstoy
May 28, 2014·FEMS Microbiology Reviews·Mirjana Rajilić-Stojanović, Willem M de Vos
Jun 19, 2014·MBio·Anna M SeekatzVincent B Young
May 16, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Robert R JenqMarcel R M van den Brink
Jul 28, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Tania JainGeorge Alangaden

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Citations

Sep 7, 2019·Scientific Reports·Sophie AmraneJean Christophe Lagier
Jan 28, 2020·Annual Review of Medicine·Zaker I Schwabkey, Robert R Jenq
Jul 10, 2019·Open Forum Infectious Diseases·Matthew ZieglerUNKNOWN CDC Prevention Epicenters Program
Mar 30, 2018·Digestive Diseases and Sciences·Rafael AraosErika M C D'Agata
Oct 26, 2018·Frontiers in Microbiology·J Luis EspinozaAkiyoshi Takami
Jul 15, 2020·Critical Care : the Official Journal of the Critical Care Forum·Daosheng WangYibing Peng
Sep 22, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Jason ZouChristopher F Lowe
Oct 16, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Fernanda L Paganelli, Miquel B Ekkelenkamp
Oct 2, 2020·Current Opinion in Hematology·Sarah Lindner, Jonathan U Peled
Jan 4, 2021·Current Opinion in Genetics & Development·Chi L NguyenKate A Markey
Jan 25, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Igor StomaYing Taur
Aug 28, 2021·Microorganisms·Pedro Sánchez-PellicerJuan Agüera-Santos

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