Protective function of complement against alcohol-induced rat liver damage

International Immunopharmacology
I BykovK O Lindros

Abstract

The complement system can promote tissue damage or play a homeostatic role in the clearance and disposal of damaged tissue. We assessed the role of the terminal complement pathway in alcohol-induced liver damage in complement C6 (C6-/-) genetically deficient rats. C6-/- and corresponding C6+/+ rats were continuously exposed to ethanol by feeding ethanol-supplemented liquid diet for six weeks. Liver samples were analyzed for histopathology and complement component deposition by immunofluorescence microscopy. Prostaglandin E receptors and cytokine mRNA levels were analyzed by RT-PCR and plasma cytokines by ELISA. Deposition of complement components C1, C3, C8 and C9 was observed in C6+/+ rats, but not in C6-/- animals. The histopathological changes, the liver weight increase and the elevation of the plasma pro-/anti-inflammatory TNF-alpha/IL-10 ratio were, on the other hand, more marked in C6-/- rats. Furthermore, ethanol enhanced the hepatic mRNA expression of the prostaglandin E receptors EP2R and EP4R exclusively in the C6-/- rats. Our results indicate that a deficient terminal complement pathway predisposes to tissue injury and promotes a pro-inflammatory cytokine response. This suggests that an intact complement system has a...Continue Reading

References

Jan 1, 1989·Complement and Inflammation·B P Morgan
Mar 1, 1995·Kidney International·A VäkeväP Laurila
Jan 1, 1993·Annual Review of Immunology·K W MooreT R Mosmann
Dec 1, 1995·Alcoholism, Clinical and Experimental Research·G L BirdR S Williams
Aug 1, 1997·Clinical and Experimental Immunology·M G van DixhoornM R Daha
Dec 12, 1997·Alcoholism, Clinical and Experimental Research·H A JärveläinenK O Lindros
Aug 27, 1998·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·K O Lindros, H A Järveläinen
Nov 13, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·W SchmiedtS Bhakdi
Jun 4, 1999·Seminars in Cell & Developmental Biology·K CianfloneA D Sniderman
Jan 25, 2000·The Journal of Biological Chemistry·S L Friedman
Mar 4, 2000·Molecular Immunology·C D CollardG L Stahl
Mar 4, 2000·Molecular Immunology·F Niculescu, H Rus
May 12, 2000·Immunological Reviews·P A Knolle, G Gerken
Apr 5, 2001·The New England Journal of Medicine·M J Walport
Apr 12, 2001·The New England Journal of Medicine·M J Walport
Jun 21, 2001·Immunological Reviews·H G RusM L Shin
Sep 1, 2001·Trends in Molecular Medicine·S StewartC P Day
Mar 26, 2002·Journal of the American Society of Nephrology : JASN·Masaomi NangakuWilliam G Couser
Nov 8, 2002·Trends in Molecular Medicine·Patrick L McGeer, Edith G McGeer
Dec 18, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Harri A JärveläinenSeppo Meri
May 22, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Thomas P ZwakaPeter M Jehle
Jun 28, 2003·Best Practice & Research. Clinical Gastroenterology·Christiane Bode, J Christian Bode
Sep 17, 2003·The Journal of Experimental Medicine·Christoph W StreyJohn D Lambris
Nov 15, 2003·The Journal of Biological Chemistry·Zhunan XiaKatherine Cianflone

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Citations

Dec 4, 2010·Antioxidants & Redox Signaling·Jessica I CohenLaura E Nagy
Mar 20, 2008·American Journal of Physiology. Endocrinology and Metabolism·Margaret Sozio, David W Crabb
Jan 22, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Bin GaoSamir Zakhari
Jan 12, 2007·BMC Bioinformatics·Eric YangIoannis P Androulakis
May 14, 2010·Experimental Biology and Medicine·Maxwell Afari Gyamfi, Yu-Jui Yvonne Wan
May 15, 2009·Seminars in Immunopathology·Luca ValentiSilvia Fargion
May 21, 2013·Seminars in Immunology·Julia PhielerTriantafyllos Chavakis
Jun 26, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Igor BykovSeppo Meri
Jun 7, 2006·Annals of Medicine·Igor BykovSeppo Meri
May 9, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Sunitha KodidelaSantosh Kumar
Jun 11, 2021·Immunology Letters·Lazara Elena Santiesteban-LoresLorena Bavia

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