PMID: 9430740Feb 12, 1998Paper

Protective immunity against HSV-2 in the mouse vagina

Journal of Reproductive Immunology
M B Parr, E L Parr

Abstract

Herpes simplex virus type 2 (HSV-2) is a sexually transmitted pathogen that infects the genital tract. The high prevalence of HSV-2 in humans underscores the need to develop an effective vaccine. Efforts to develop vaccines to protect women against this and other sexually transmitted pathogens would be facilitated by a better understanding of the immune mechanisms that protect the female reproductive tract against infections in animal models. Such information would be invaluable in developing vaccine strategies to promote the type and magnitude of immune responses in the genital tract that would effectively protect against infection. This review focuses on recent studies using a progestin-treated adult mouse model to explore mucosal immunity to HSV-2 in the vagina. Evidence indicating a major role for both humoral and T cell immunity is presented.

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Citations

Sep 10, 2013·Trends in Immunology·Haina Shin, Akiko Iwasaki
Dec 20, 2005·Viral Immunology·Veronica MasCasulloBetsy C Herold
Jan 15, 2004·Obstetrics and Gynecology Clinics of North America·Gretchen S Stuart, Paula M Castaño
Mar 20, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ruchi SrivastavaLbachir BenMohamed
May 20, 2014·Expert Review of Vaccines·William P Halford
Sep 29, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiuli ZhangLbachir Benmohamed
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·P HärleD J Carr
May 25, 1999·Infection and Immunity·P L FidelF Wormley

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