PMID: 8962121Dec 10, 1996Paper

Protective immunity to HIV-1 in SCID/beige mice reconstituted with peripheral blood lymphocytes of exposed but uninfected individuals

Proceedings of the National Academy of Sciences of the United States of America
C ZhangL J Chang

Abstract

Immunodeficiency typically appears many years after initial HIV infection. This long, essentially asymptomatic period contributes to the transmission of HIV in human populations. In rare instances, clearance of HIV-1 infection has been observed, particularly in infants. There are also reports of individuals who have been frequently exposed to HIV-1 but remain seronegative for the virus, and it has been hypothesized that these individuals are resistant to infection by HIV-1. However, little is known about the mechanism of immune clearance or protection against HIV-1 in these high-risk individuals because it is difficult to directly demonstrate in vivo protective immunity. Although most of these high-risk individuals show an HIV-1-specific cell-mediated immune response using in vitro assays, their peripheral blood lymphocytes (PBLs) are still susceptible to HIV infection in tissue culture. To study this further in vivo, we have established a humanized SCID mouse infection model whereby T-, B-, and natural killer-cell defective SCID/beige mice that have been reconstituted with normal human PBLs can be infected with HIV-1. When the SCID/beige mice were reconstituted with PBLs from two different multiply exposed HIV-1 seronegative i...Continue Reading

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Citations

Jul 20, 2002·Current Infectious Disease Reports·M. Patricia D'SouzaMargaret I. Johnston
Apr 15, 1999·Immunology Letters·M ClericiS Mazzoli
May 2, 2002·Vaccine·Tomás HankeRachel V Samuel
Mar 6, 1999·Current Opinion in Microbiology·J N SimonsenF A Plummer
Oct 31, 2003·AIDS Research and Human Retroviruses·Seth H PincusTamera K Marcotte
Jul 14, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Marie NguyenGianfranco Pancino
Nov 5, 1998·The Journal of Clinical Investigation·S L Rowland-JonesF A Plummer
Jul 6, 2004·Immunological Reviews·Marie J EstcourtTomás Hanke
Nov 21, 2001·British Medical Bulletin·P Hansasuta, S L Rowland-Jones
Jan 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·R KaulS L Rowland-Jones

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