Protective immunity to Schistosoma japonicum infection depends on the balance of T helper cytokine responses in mice vaccinated with gamma-irradiated cercariae

Parasite Immunology
Y OsadaS Kojima

Abstract

Although the strain difference in protection of mice to Schistosoma mansoni infection has been described, limited information is available in the case of Schistosoma japonicum. In the present study, we compared the protective immunity to S. japonicum infection and cytokine production in various strains of mice vaccinated with gamma-irradiated cercariae. A significant reduction in worm recovery was observed in male and female mice of DBA/2 at a 6-week interval between vaccination and a challenge infection, whereas vaccinated mice of C57BL/6, C57BL/10, (C57BL/6 x DBA/2) F1 (B6D2F1) and (C57BL/10 x DBA/2) F1 (B10D2F1) showed no detectable level of protection. No sex-linked difference in development of resistance was observed in any of the strains so far examined. Vaccination with gamma-irradiated cercariae twice with a 3-week interval also induced significant protection against a challenge infection in DBA/2 but not in BALB/c or C57BL/6 strains. Further studies demonstrated that spleen cells of vaccinated C57BL/6 mice produced lower levels of IFN-gamma compared to the cells of vaccinated BALB/c and DBA/2. On the other hand, production of IL-10 by spleen cells was relatively higher in BALB/c mice than in the other two strains. Macr...Continue Reading

References

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Citations

Jul 20, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Supriya M PerambakamDavid J Peace
Apr 15, 2004·Parasitology International·Somei Kojima
Apr 15, 2004·Parasitology International·Nobuo OhtaRenli Zhang
Apr 15, 2020·International Review of Psychiatry·Gaia SampognaAndrea Fiorillo
Apr 11, 2008·Acta Biochimica Et Biophysica Sinica·Mahmoud H RomeihMohamed A Saber
Jan 11, 2007·Acta Biochimica Et Biophysica Sinica·Gan DaiFen Liu

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