PMID: 8587800Jan 1, 1996Paper

Protective immunity to Schistosoma mansoni induced in the olive baboon Papio anubis by the irradiated cercaria vaccine

Parasitology
Dorcas S YoleR A Wilson

Abstract

The radiation-attenuated schistosome vaccine induces a high level of protective immunity in rodents. In order to assess its potential relevance to man, we have tested its efficacy in the non-human primate Papio anubis. A vaccination regime consisting of 3 exposures of approximately 9000 cercariae irradiated with 30 or 60 krad. of gamma radiation induced > 50% protection to a challenge with normal larvae. A lower attenuating dose of 20 krad., optimal for vaccination of mice, was less effective. All vaccination regimes elicited a population of PBMC which proliferated in vitro in response to antigen. These responses peaked after the third exposure but were significantly lower after challenge. They revealed relatively little cross-reactivity with adult Schistosoma haematobium antigens and provided some evidence for stage-specific antigens. Circulating IgM reactive with adult S. mansoni antigen was detected after the second vaccination but levels remained low throughout. In contrast, IgG levels were boosted by successive vaccinations, although they showed a tendency to decline from 14 days after each exposure. There also appeared to be a lag of about 14 days after challenge before levels began to rise. Thus, both proliferation and a...Continue Reading

References

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Citations

Jan 8, 1999·Acta Tropica·F G AbathY M Gomes
Nov 11, 1999·Parasitology Today·M Nyindo, I O Farah
Dec 22, 1999·Microbes and Infection·R A Wilson, P S Coulson
Jun 23, 2006·Infection and Immunity·Thomas M KariukiPatricia S Coulson
Aug 24, 2004·Infection and Immunity·Thomas M KariukiPatricia S Coulson
Sep 30, 2008·PLoS Neglected Tropical Diseases·R Alan WilsonPatricia S Coulson
Nov 5, 1997·The Pediatric Infectious Disease Journal·P J HotezJ Bethony
Feb 9, 2008·Parasitology Research·Afzal A SiddiquiRonald C Kennedy
Feb 19, 2016·Parasites & Vectors·R Alan WilsonWilliam Castro-Borges
Sep 1, 2009·Trends in Parasitology·R Alan Wilson, Patricia S Coulson
Jan 5, 2011·Immunological Reviews·Jeffrey M BethonyPeter J Hotez
Oct 4, 2005·Vaccine·Krishna K MurthyJean L Patterson
Apr 5, 2014·Lancet·Daniel G ColleyCharles H King
Mar 17, 2015·Frontiers in Immunology·Mizuho FukushigeFrancisca Mutapi
Feb 20, 2007·Memórias do Instituto Oswaldo Cruz·Patricia S Coulson, Thomas M Kariuki
Sep 22, 2018·Parasite Immunology·Moses EgesaStephen Cose
May 30, 2008·Journal of Medical Primatology·M M JenebyH E Carlson
Sep 6, 2005·Parasite Immunology·J P HewitsonA P Mountford
Nov 22, 2018·Frontiers in Immunology·Christian Schwartz, Padraic G Fallon
Jul 28, 2019·Experimental Parasitology·Christopher Khayeka-WandabwaChristopher O Anjili
Dec 22, 2017·Emerging Topics in Life Sciences·R Alan WilsonWilliam Castro-Borges
Nov 5, 1999·Clinical and Diagnostic Laboratory Immunology·M H ShearerR C Kennedy

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