Protective immunization against chronic Pseudomonas aeruginosa pulmonary infection in rats.

Infection and Immunity
J D KlingerJ J Miler

Abstract

Rats were immunized systemically with various doses of the polyvalent Pseudomonas aeruginosa vaccine PEV-01. After a series of two or three doses (25 to 50 micrograms each) at 8- to 11-day intervals, animals were challenged intratracheally by the agarose bead technique with a serotype 5 P. aeruginosa strain at periods of 9 to 42 days. Immunized animals developed circulating antibodies (primarily immunoglobulin M) against vaccine components at levels significantly higher than challenged, nonimmunized controls (P less than 0.005). Eight to ten days postinfection, histological sections of lungs from immunized animals showed only minimal inflammation associated with infectious foci (agarose beads) as compared with the extensive pathological changes of airways and parenchyma seen in infected nonimmunized control animals. However, no significant reduction in bacterial numbers was observed. Such protection lasted at least 6 weeks after the final immunization. It is speculated that the vaccine may contain components of cell surface proteins and virulence exoproducts.

References

Sep 1, 1979·Infection and Immunity·J E Pennington, J J Miler
Feb 1, 1977·Journal of Medical Microbiology·J M MilerE J Lowbury
Jul 1, 1977·Journal of Clinical Microbiology·M Pollack, N S Taylor
Mar 1, 1978·Infection and Immunity·M Pollack, S E Anderson
May 1, 1975·The American Journal of Medicine·J E PenningtonA S Levine
Jun 1, 1976·The Journal of Hygiene·R J JonesJ F Spilsbury
Feb 22, 1975·British Medical Journal·H McFarlaneB Worsley
Oct 1, 1973·The Journal of Infectious Diseases·P V Liu, H Hsieh
Jan 1, 1974·Vox Sanguinis·B Pirofsky, E R Rosner
Jul 1, 1973·CRC Critical Reviews in Clinical Laboratory Sciences·P NathanB G MacMillan
Jan 1, 1971·Archives of Surgery·J W AlexanderB G MacMillan
May 1, 1980·Infection and Immunity·P B Fernandes, K R Cundy
Jun 1, 1980·Pediatric Research·M BerdischewskyE V Barnett
Aug 1, 1980·The Journal of Infectious Diseases·J E Pennington, D Kuchmy
May 1, 1982·The American Review of Respiratory Disease·P J HeidbrinkA K Pierce
Jan 31, 1980·The New England Journal of Medicine·W J MatthewsH R Colten
Mar 1, 1965·Journal of General Microbiology·A H WAHBA, J H DARRELL

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Citations

Sep 1, 1987·Pediatric Pulmonology·M J ThomassenC F Doershuk
Jul 16, 2005·Expert Opinion on Biological Therapy·E Sedlak-WeinsteinA R Foxwell

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