Protective immunosurveillance and therapeutic antitumor activity of gammadelta T cells demonstrated in a mouse model of prostate cancer

The Journal of Immunology : Official Journal of the American Association of Immunologists
Zhiyong LiuRichard D Lopez

Abstract

In contrast to Ag-specific alphabeta T cells, gammadelta T cells can kill malignantly transformed cells in a manner that does not require the recognition of tumor-specific Ags. Although such observations have contributed to the emerging view that gammadelta T cells provide protective innate immunosurveillance against certain malignancies, particularly those of epithelial origin, they also provide a rationale for developing novel clinical approaches to exploit the innate antitumor properties of gammadelta T cells for the treatment of cancer. Using TRAMP, a transgenic mouse model of prostate cancer, proof-of-concept studies were performed to first establish that gammadelta T cells can indeed provide protective immunosurveillance against spontaneously arising mouse prostate cancer. TRAMP mice, which predictably develop prostate adenocarcinoma, were backcrossed with gammadelta T cell-deficient mice (TCRdelta(-/-) mice) yielding TRAMP x TCRdelta(-/-) mice, a proportion of which developed more extensive disease compared with control TRAMP mice. By extension, these findings were then used as a rationale for developing an adoptive immunotherapy model for treating prostate cancer. Using TRAMP-C2 cells derived from TRAMP mice (C57BL/6 ge...Continue Reading

References

Feb 15, 1995·Journal of the National Cancer Institute·M G SandaJ W Simons
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·N M GreenbergJ M Rosen
Jul 1, 1996·Toxicologic Pathology·J R Gingrich, N M Greenberg
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·V GrohT Spies
Jan 5, 2000·Seminars in Surgical Oncology·B A Tjoa, G P Murphy
Aug 8, 2001·Current Oncology Reports·B I Rini, E J Small
Sep 22, 2001·Science·M GirardiA C Hayday
Apr 26, 2003·The Journal of Investigative Dermatology·Katy ArgentatiMauro Provinciali
Aug 6, 2003·The Journal of Experimental Medicine·Yunfei GaoZhinan Yin
Jan 10, 2004·The Journal of Urology·Kent G KrejciEugene D Kwon
Sep 28, 2005·Breast Cancer Research and Treatment·Ben L GuoRichard D Lopez
Jan 19, 2006·The Journal of Investigative Dermatology·Michael Girardi
Jul 28, 2006·Current Opinion in Immunology·Marc Bonneville, Emmanuel Scotet
Jan 11, 2007·Cancer Research·Dieter KabelitzWei He
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael J AndersonArthur A Hurwitz
Aug 25, 2007·Journal of Immunological Methods·Samuel SalotJérôme Tiollier

❮ Previous
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Citations

Oct 20, 2009·Proceedings of the National Academy of Sciences of the United States of America·Rajeev M NepalAlberto Martin
Feb 10, 2010·Cancer Metastasis Reviews·Varinder JeetAparajita Khatri
Oct 12, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Diego Marquez-MedinaAntonieta Salud-Salvia
Oct 16, 2012·British Journal of Haematology·Mounia S Braza, Bernard Klein
May 21, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Telma LançaBruno Silva-Santos
Feb 4, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julie C RibotBruno Silva-Santos
Oct 10, 2015·Nature Reviews. Immunology·Bruno Silva-SantosHåkan Norell
Aug 6, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexandra Audemard-VergerBruno Martin
Aug 28, 2009·Immunologic Research·Lawrence S Lamb
Feb 15, 2012·Cancer Immunology, Immunotherapy : CII·Nicolò Rigamonti, Matteo Bellone
Jun 2, 2015·Expert Opinion on Drug Discovery·Kenneth C Valkenburg, Kenneth J Pienta
Jul 1, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amélie LombesBruno Martin
Jul 5, 2017·Biomedicines·Haitham AbdelhakimAyman Saad
Nov 24, 2017·BMC Cancer·S R SaifuddinM Van Hemelrijck
Jul 10, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adrian C Hayday
Jul 18, 2009·Journal of Neuroscience Research·Jillian E WohlerScott R Barnum
Dec 26, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chiara AgratiFederico Martini
Aug 13, 2014·Proceedings of the National Academy of Sciences of the United States of America·Margarida ReiBruno Silva-Santos
Jul 25, 2009·Nature Reviews. Immunology·David H Raulet, Nadia Guerra
Jun 19, 2019·Nature Reviews. Cancer·Bruno Silva-SantosSeth B Coffelt
Jun 26, 2013·Immunology and Cell Biology·Daniel W FowlerMark D Bodman-Smith
May 21, 2013·Cancer Immunology, Immunotherapy : CII·Carol InatsukaHailing Lu
Oct 27, 2017·Proceedings of the National Academy of Sciences of the United States of America·Dorien Van HedeNathalie Jacobs
Nov 15, 2020·European Journal of Immunology·Noëlla Lopes, Bruno Silva-Santos
Aug 7, 2013·Cancer Prevention Research·Edmond MarzbaniMary L Disis
Mar 13, 2021·Experimental & Molecular Medicine·Jang Hyun Park, Heung Kyu Lee
Jun 3, 2021·Revista brasileira de ginecologia e obstetrícia : revista da Federação Brasileira das Sociedades de Ginecologia e Obstetrícia·Polyana Barbosa SilvaEddie Fernando Cândido Murta

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