Protective Impact of Edaravone Against ZnO NPs-induced Oxidative Stress in the Human Neuroblastoma SH-SY5Y Cell Line

Cellular and Molecular Neurobiology
Sanjiv SinghF V Manvi

Abstract

Extensive applications of ZnO NPs (zinc oxide nanoparticles) in daily life have created concern about their biotoxicity. Zinc oxide nanoparticles induce oxidative stress, inflammation, and apoptosis in neurons. Edaravone applies antioxidant agent and anti-inflammatory impacts in the different cells, as evaluated in both in vitro and in vivo experimental models. This study is designed to explore, how edaravone would avert mitochondrial impairment in human neuronal cells against ZnO NPs-induced toxicity. Accordingly, we analyzed here whether a pretreatment (for 24 h) with edaravone (10-100 μM) would enhance mitochondrial protection in the human neuroblastoma cells SH-SY5Y against ZnO NPs-induced toxicity. We found that edaravone at 25 μM averted the ZnO NPs-induced decrease in the amounts of adenosine triphosphate (ATP), just as on the activity of the complexes I and V. Also, edaravone induced an antioxidant activity by diminishing the levels of lipid peroxidation, protein carbonylation, and protein nitration in the mitochondrial membranes. Edaravone blocked the ZnO NPs-induced transcription factor nuclear factor-κB (NF-κB) upregulation. The inhibition of the heme oxygenase-1 (HO-1) enzyme by zinc protoporphyrin IX (ZnPP IX, 10 μ...Continue Reading

References

Oct 2, 2003·Nature Biotechnology·Vicki L Colvin
Nov 26, 2003·Biochemical and Biophysical Research Communications·Jan C BeckerThorsten Pohle
Feb 10, 2004·The Journal of Physiology·Simon J Gibbons, Gianrico Farrugia
Mar 15, 2005·Free Radical Research·Shali ChenSubrata Chakrabarti
Feb 8, 2006·American Journal of Physiology. Renal Physiology·Kristin A Kirkby, Christopher A Adin
Jul 11, 2006·Trends in Molecular Medicine·Fritz H Bach
Sep 19, 2006·American Journal of Respiratory Cell and Molecular Biology·Stefan W RyterAugustine M K Choi
May 8, 2009·Nanotechnology·Xiaoyong DengZheng Jiao
Aug 19, 2010·Expert Opinion on Drug Delivery·John W RasmussenDenise G Wingett
Aug 28, 2010·Nanotoxicology·Megan J Osmond, Maxine J McCall
Mar 2, 2011·The Journal of Experimental Medicine·Edwina Naik, Vishva M Dixit
Apr 7, 2011·European Journal of Immunology·Jürg Tschopp
Feb 26, 2013·Free Radical Biology & Medicine·Suryakant K NitureAnil K Jaiswal
Mar 29, 2013·Environment International·Vanessa ValdiglesiasJoão Paulo Teixeira
May 28, 2014·Journal of Biomedical Materials Research. Part a·Kaveh MemarzadehRobert P Allaker
Sep 23, 2014·Science·Douglas R GreenGuido Kroemer
Jan 8, 2015·International Journal of Nanomedicine·Kyu Hwan ShimSeong Soo A An
Mar 3, 2015·Trends in Endocrinology and Metabolism : TEM·Luke O'BrienTerry D Hinds
Jul 7, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Violet Aileen SenapatiAlok Dhawan

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