Protective responses in mice to vaccination with multiply administered cold-adapted influenza vaccine reassortants and wild-type viruses

Vaccine
Julia RomanovaG I Alexandrova

Abstract

Protective responses to influenza vaccine reassortants derived from the cold-adapted (ca) donor strains A/Leningrad/134/17/57 and B/USSR/60/69 and wild-type epidemic viruses were studied in two strains of mice. Preliminary experiments revealed that, when mixtures of three viruses were inoculated intranasally to mice with 50 microliters containing 10(6) EID50 per 200 microliters (10(5.4) EID50 per mouse), interference between strains did not occur. However, interference with the growth of the influenza reassortant B/60/32/R took place if its concentration in the mixture was reduced to 10(5) (10(4.4) per mouse) or if it was inoculated at 10(6) EID50 (10(5.4) per mouse) in the presence of the influenza reassortant R/34 and two other influenza A epidemic strains; interference was unrelated to serological responses to infection with B/60/32/R. Despite evidence of interference, mice inoculated with the same mixtures in two identical doses, three weeks apart, were able to clear a challenge from each of seven homotypic and heterotypic influenza A and B strains. Heterotypic clearance of influenza A challenge viruses was greater following mixed infection, indicating that common determinants within the surface antigen glycoproteins contri...Continue Reading

References

Jan 1, 1982·Archives of Virology·A Mikheeva, Y Z Ghendon

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Citations

Aug 23, 2001·Advanced Drug Delivery Reviews·S S Davis
May 12, 2001·Vaccine·M D Wareing, G A Tannock
May 26, 2004·Microbes and Infection·Taisuke HorimotoYoshihiro Kawaoka
May 26, 2009·Vaccine·Sarah A Kopecky-BrombergPeter Palese
Aug 24, 2018·Journal of Virology·Zhimin WanDaniel R Perez

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