Protective role of anti-ribosomal P antibody in patients with lupus nephritis

International Journal of Rheumatic Diseases
Ji-Hyoun KangShin-Seok Lee

Abstract

The aim of this study was to define clinical, histopathologic, and prognostic differences according to the presence of anti-ribosomal P antibody (anti-P) in Korean patients with biopsy-proven lupus nephritis (LN). We studied 79 patients who underwent kidney biopsies prior to the start of induction treatment, and who were subsequently treated with immunosuppressive drugs for at least 6 months and followed-up for more than 6 months. Anti-P was measured by immunoblot analysis at the time of renal biopsy. Of all patients, 35.4% were anti-P-positive. Such patients exhibited earlier LN onset, a higher Systemic Lupus Erythematosus Disease Activity Index 2000 score, and a higher estimated glomerular filtration rate at the time of renal biopsy, than did those without antibodies. Upon renal histopathological analysis, patients with anti-P exhibited less interstitial inflammation in terms of the activity index, less glomerular sclerosis, less tubular atrophy, and less interstitial fibrosis in terms of the chronicity index. Furthermore, anti-P was associated with lower chronicity scores. At a median follow-up time of 47 months, renal function was preserved in 27 of 28 patients who had anti-P, but only 38 of 51 patients without such antibod...Continue Reading

References

Mar 7, 1968·The New England Journal of Medicine·P H Schur, J Sandson
Sep 1, 1983·The American Journal of Medicine·H A AustinJ E Balow
Jul 1, 1998·Clinical Immunology and Immunopathology·V ChindaloreM Reichlin
Jul 17, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Morris Reichlin, Marianne Wolfson-Reichlin
Jan 30, 2004·Journal of the American Society of Nephrology : JASN·Jan J WeeningMichio Nagata
Mar 1, 2005·Lupus·M Waldman, M P Madaio
Jul 12, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Morris Reichlin
Feb 3, 2006·Arthritis and Rheumatism·UNKNOWN Renal Disease Subcommittee of the American College of Rheumatology Ad Hoc Committee on Systemic Lupus Erythematosus Response
Sep 14, 2010·Autoimmunity Reviews·Patrícia Andrade de MacedoEloísa Bonfá
Feb 11, 2011·Arthritis Care & Research·Christine HsiehMarcus R Clark
Nov 14, 2012·Nature Reviews. Nephrology·Ben SprangersGerald B Appel
Mar 26, 2014·Journal of Autoimmunity·Dana Ben-Ami ShorYehuda Shoenfeld
Apr 10, 2018·Reviews on Recent Clinical Trials·Sabahat SarfarazRana Muzaffar

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Citations

Nov 12, 2020·Lupus·Gali AljadeffYehuda Shoenfeld
Jan 14, 2020·Autoimmunity Reviews·May Y ChoiMarvin J Fritzler
Jul 7, 2021·Journal of Neuroimmunology·Xinnan Zhao, Pingting Yang

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