Protective role of berberine on ulcerative colitis through modulating enteric glial cells-intestinal epithelial cells-immune cells interactions

Acta Pharmaceutica Sinica. B
Heng LiWei Tang

Abstract

Ulcerative colitis (UC) manifests as an etiologically complicated and relapsing gastrointestinal disease. The enteric nervous system (ENS) plays a pivotal role in rectifying and orchestrating the inflammatory responses in gut tract. Berberine, an isoquinoline alkaloid, is known as its anti-inflammatory and therapeutic effects in experimental colitis. However, little research focused on its regulatory function on ENS. Therefore, we set out to explore the pathological role of neurogenic inflammation in UC and the modulating effects of berberine on neuro-immune interactions. Functional defects of enteric glial cells (EGCs), with decreased glial fibrillary acidic protein (GFAP) and increased substance P expression, were observed in DSS-induced murine UC. Administration of berberine can obviously ameliorate the disease severity and restore the mucosal barrier homeostasis of UC, closely accompanying by maintaining the residence of EGCs and attenuating inflammatory infiltrations and immune cells overactivation. In vitro, berberine showed direct protective effects on monoculture of EGCs, bone marrow-derived dendritic cells (BMDCs), T cells, and intestinal epithelial cells (IECs) in the simulated inflammatory conditions. Furthermore, be...Continue Reading

Citations

Dec 8, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Wanghui JingHaitao Lu
Oct 17, 2020·Mediators of Inflammation·Li JiaAhmed E Abdel Moneim
Sep 19, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yuanna ShenHaiyan Hu
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Laura López-GómezRaquel Abalo

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Methods Mentioned

BETA
IECs
biopsy
ELISA
MDA
biopsies
flow cytometry
protein assay
PCR
electrophoresis
IEC

Clinical Trials Mentioned

NCT02962245
NCT02365480

Software Mentioned

FlowJo
GraphPad Prism

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