Protective Role of Enalapril in Anthracycline-Induced Cardiotoxicity: A Systematic Review

Frontiers in Pharmacology
Yili ZhangYong Wang

Abstract

Evidence of the preventive and therapeutic effects of enalapril on cardiotoxicity caused by chemotherapy needs to be further confirmed and updated. We performed a systematic review of studies from electronic databases that were searched from inception to January 29, 2019, and included relevant studies analyzing enalapril as a cardioprotective agent before or during the use of anthracyclines by oncology patients. Homogeneous results from different studies were pooled using RevMan 5.3 software. The Cochrane risk-of-bias tool was used to determine the quality of the studies. We examined and screened 626 studies according to specific criteria and ultimately included seven studies that were relevant to the indicated topic. Among them, three studies reported the incidence of death during 6- and 12-month follow-up periods. Six of the seven included studies showed possible positive results, suggesting that enalapril plays a cardioprotective role, while five of these studies showed that there was a significant difference in the left ventricular ejection fraction (LVEF) between an enalapril group and a control group (weighted mean difference (WMD) = 7.18, 95% CI: 2.49-11.87, I2 = 96%, P < .001). Moreover, enalapril was beneficial in redu...Continue Reading

References

Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey H SilberHuaqing Zhao
Feb 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cameron K TebbiCindy L Schwartz
Jun 26, 2012·International Journal of Cardiology·Mehmet G KayaYat Yin Lam
Mar 24, 2016·Cardiovascular Toxicology·Ghasem JanbabaiJamshid Yazdani
Apr 28, 2016·The Canadian Journal of Cardiology·Rohit Moudgil, Edward T H Yeh
Jun 28, 2016·Archives of Toxicology·Roberto Marques DamianiJenifer Saffi
Jul 16, 2017·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Friedrich C Luft
Mar 24, 2018·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Daniela CardinaleUNKNOWN ICOS-ONE Study Investigators
Feb 25, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lauren TomlinsonParveen Sharma
Mar 1, 2019·Toxicology Letters·Mei SongboShao Liang
May 15, 2019·Current Opinion in Cardiology·Robert S Copeland-HalperinAnthony F Yu

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Citations

Sep 11, 2020·International Journal of Clinical Pharmacy·Azin AlizadehaslHossein Hosseinifard

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Software Mentioned

Cochrane
ONE
RevMan

Related Concepts

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Cardiotoxicity

Cardiotoxicity refers to the muscle damage or dysfunction of heart electrophysiology caused by drug intake or due to disease complications. It is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. Here is the latest research.

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