Protective Role of False Tendon in Subjects with Left Bundle Branch Block: A Virtual Population Study

PloS One
Matthias LangeAlejandro F Frangi

Abstract

False tendons (FTs) are fibrous or fibromuscular bands that can be found in both the normal and abnormal human heart in various anatomical forms depending on their attachment points, tissue types, and geometrical properties. While FTs are widely considered to affect the function of the heart, their specific roles remain largely unclear and unexplored. In this paper, we present an in silico study of the ventricular activation time of the human heart in the presence of FTs. This study presents the first computational model of the human heart that includes a FT, Purkinje network, and papillary muscles. Based on this model, we perform simulations to investigate the effect of different types of FTs on hearts with the electrical conduction abnormality of a left bundle branch block (LBBB). We employ a virtual population of 70 human hearts derived from a statistical atlas, and run a total of 560 simulations to assess ventricular activation time with different FT configurations. The obtained results indicate that, in the presence of a LBBB, the FT reduces the total activation time that is abnormally augmented due to a branch block, to such an extent that surgical implant of cardiac resynchronisation devices might not be recommended by i...Continue Reading

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Citations

Sep 24, 2016·International Journal for Numerical Methods in Biomedical Engineering·M LangeA F Frangi
Jul 31, 2019·Scientific Reports·Yongheng WangHao Gao

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Software Mentioned

TetGen
QRS Diff
GIMIAS

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