Protective role of glutathione reductase in paraquat induced neurotoxicity

Chemico-biological Interactions
Mirjana M DjukicJelena Vekic

Abstract

Paraquat (PQ), a widely used herbicide is a well-known free radical producing agent. The mechanistic pathways of PQ neurotoxicity were examined by assessing oxidative/nitrosative stress markers. Focus was on the role of glutathione (GSH) cycle and to examine whether the pre-treatment with enzyme glutathione reductase (GR) could protect the vulnerable brain regions (VBRs) against harmful oxidative effect of PQ. The study was conducted on Wistar rats, randomly divided in five groups: intact-control group, (n = 8) and four experimental groups (n = 24). All tested compounds were administered intrastriatally (i.s.) in one single dose. The following parameters of oxidative status were measured in the striatum, hippocampus and cortex, at 30 min, 24 h and 7 days post treatment: superoxide anion radical (O₂·⁻), nitrate (NO₃⁻), malondialdehyde (MDA), superoxide dismutase (SOD), total GSH (tGSH) and its oxidized, disulfide form (GSSG) and glutathione peroxidase (GPx). Results obtained from the intact and the sham operated groups were not statistically different, confirming that invasive i.s. route of administration would not influence the reliability of results. Also, similar pattern of changes were observed between ipsi- and contra- late...Continue Reading

References

Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·N R BachurH Kon
Aug 22, 1977·Biochemical and Biophysical Research Communications·J MaralA M Michelson
Nov 1, 1992·Human & Experimental Toxicology·M T CorasanitiG Nisticò
Jun 1, 1990·The Journal of Clinical Investigation·R KannanN Kaplowitz
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A JainA Meister
Jan 1, 1990·Human & Experimental Toxicology·P HouzéJ M Scherrmann
Mar 17, 1988·Biochimica Et Biophysica Acta·K Olafsdottir, D J Reed
Sep 1, 1985·The Journal of Clinical Investigation·I U SchraufstätterC G Cochrane
Feb 1, 1974·Journal of Neurochemistry·J W GurdW J Moore
Jan 1, 1981·Methods in Enzymology·A MeisterO W Griffith
Apr 1, 1984·Environmental Health Perspectives·H P Witschi, P J Hakkinen
Jan 29, 1982·Biochemical and Biophysical Research Communications·N ElsayedG Schrauzer
Sep 1, 1981·Journal of Neurochemistry·L A Wade, H M Brady
Dec 1, 1994·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·T FukushimaY Yamane
May 1, 1995·Free Radical Biology & Medicine·D LiuD J McAdoo
Jul 1, 1994·Free Radical Biology & Medicine·J P Kehrer, L G Lund
May 30, 1994·Biochemical and Biophysical Research Communications·B V ZlokovicR Kannan
Feb 1, 1993·Archives of Environmental Contamination and Toxicology·H BabichA Stern
Jul 24, 1998·Protein Expression and Purification·I Misra, O W Griffith
Dec 1, 1998·Journal of Neurochemistry·S R EnnisR F Keep
Apr 12, 2000·European Journal of Biochemistry·D SommerP M Stemmer
Jul 6, 2000·Progress in Neurobiology·R Dringen
Feb 15, 2001·Nature Cell Biology·S R JaffreyS H Snyder
Jan 19, 2002·IUBMB Life·J T GreenamyreA V Panov
Jun 18, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Anna PastoreFiorella Piemonte

❮ Previous
Next ❯

Citations

Jul 26, 2013·Indian Journal of Pediatrics·Wei GeRuo-peng Sun
Oct 15, 2014·International Journal of Molecular Sciences·Min HuangZhijun Zhou
Feb 9, 2016·Autonomic Neuroscience : Basic & Clinical·Lucy DissMark Yeoman
Mar 8, 2016·Life Sciences·Ines Elbini DhouibMohamed Montassar Lasram
Sep 20, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ana DjuricMirjana Djukic
Sep 22, 2015·Frontiers in Cellular Neuroscience·Iva BozicIrena Lavrnja
Apr 24, 2014·Biochemical and Biophysical Research Communications·Teng WeiGuanghong Xie
Sep 28, 2013·Chemico-biological Interactions·Ivana StevanovicDubravko Bokonjic
Jan 20, 2017·Journal of Enzyme Inhibition and Medicinal Chemistry·Aida BegicLuciano Saso
Apr 6, 2017·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Vasco BrancoCristina Carvalho
Oct 23, 2018·Experimental and Therapeutic Medicine·Honggang Chen, Xiaoyan Fu
Aug 25, 2018·Oxidative Medicine and Cellular Longevity·Ervin TasoDragana Vujanovic
Sep 19, 2020·Luminescence : the Journal of Biological and Chemical Luminescence·Jiadi SunXiulan Sun
Nov 3, 2020·Journal of Occupational Medicine and Toxicology·Joel Salazar-FloresErandis D Torres-Sánchez
Dec 10, 2020·Journal of Occupational Medicine and Toxicology·Joel Salazar-FloresErandis D Torres-Sánchez
Mar 25, 2021·Cellular and Molecular Neurobiology·Milica Manojlovic-StojanoskiDanijela Laketa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Adenomatous Polyposis Coli

Adenomatous polyposis coli is a protein encoded by the APC gene and acts as a tumor suppressor. Discover the latest research on adenomatous polyposis coli here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

ALS: Pathogenic Mechanisms

Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.