Protective role of melatonin supplementation against nicotine-induced liver damage in mouse

Toxicology and Industrial Health
Sevcan Mercan, Banu Eren

Abstract

The present study was carried out to determine histopathological effects of nicotine, one of the most significant components of tobacco, on mouse liver and ameliorative effect of melatonin on liver damage. A total of 140 mature Swiss Albino mice (Mus musculus) were divided into four experimental groups: control group, nicotine group, melatonin group and nicotine + melatonin group. Each group was further subdivided into seven groups (five mice each) according to the time of killing (12 h and days 1, 3, 5, 7, 14 and 21 after drug administration). In nicotine and nicotine + melatonin groups, 3 mg/kg of nicotine was injected intraperitoneally every day until killing. The nicotine + melatonin group was additionally injected with 10 mg/kg of melatonin after 30 min of nicotine injection. The melatonin group was injected only with 10 mg/kg of melatonin every day until killing. All the treatments were given 2 h before sunset, when melatonin receptors were active. After the last injection, five mice from each group were killed at 12th hour and on days 1, 3, 5, 7, 14 and 21; the livers were removed for histopathological processing by light microscopy. The histopathological results revealed time-dependent degeneration in the livers of mice...Continue Reading

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Citations

Jan 26, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Eduardo Esteban-ZuberoRussel J Reiter
Sep 23, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Pinar KuruOzgur Kasimay
Mar 7, 2021·Environmental Science and Pollution Research International·Aya Khalil HendawyHodallah Hatem Ahmed
Aug 26, 2021·Environmental Science and Pollution Research International·Shimaa KhaledManar A Nader

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Methods Mentioned

BETA
light microscopy

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