Protective role of murine norovirus against Pseudomonas aeruginosa acute pneumonia

Veterinary Research
Marion ThépautBenoit Guery

Abstract

The murine norovirus (MNV) is a recently discovered mouse pathogen, representing the most common contaminant in laboratory mouse colonies. Nevertheless, the effects of MNV infection on biomedical research are still unclear. We tested the hypothesis that MNV infection could alter immune response in mice with acute lung infection. Here we report that co-infection with MNV increases survival of mice with Pseudomonas aeruginosa acute lung injury and decreases in vivo production of pro-inflammatory cytokines. Our results suggest that MNV infection can deeply modify the parameters studied in conventional models of infection and lead to false conclusions in experimental models.

References

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Citations

Jan 5, 2017·Experimental Animals·Daniele Masselli RodriguesMarcus Alexandre Finzi Corat
Sep 6, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jessica A Neil, Ken Cadwell
Jun 12, 2019·Nature Microbiology·Jessica A NeilKen Cadwell
Oct 23, 2019·Frontiers in Microbiology·Deepak SumbriaBarry T Rouse

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Methods Mentioned

BETA
bronchoalveolar lavage
lavage
optical microscopy
enzyme-linked immunosorbent Assay
ELISA

Software Mentioned

Prism
- Pad
Graph

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