Protective role of γδ T cells in cigarette smoke and influenza infection

Mucosal Immunology
M J HongFarrah Kheradmand

Abstract

Airborne pathogens commonly trigger severe respiratory failure or death in smokers with lung disease. Cigarette smoking compromises the effectiveness of innate immunity against infections but the underlying mechanisms responsible for defective acquired immune responses in smokers remains less clear. We found that mice exposed to chronic cigarette smoke recovered poorly from primary Influenza A pneumonia with reduced type I and II interferons (IFNs) and viral-specific immunoglobulins, but recruited γδ T cells to the lungs that predominantly expressed interleukin 17A (IL-17A). Il-17a-/- mice exposed to smoke and infected with Influenza A also recruited γδ T cells to the lungs, but in contrast to wild-type mice, expressed increased IFNs, made protective influenza-specific antibodies, and recovered from infection. Depletion of IL-17A with blocking antibodies significantly increased T-bet expression in γδ T cells and improved recovery from acute Influenza A infection in air, but not smoke-exposed mice. In contrast, when exposed to smoke, γδ T cell deficient mice failed to mount an effective immune response to Influenza A and showed increased mortality. Our findings demonstrate a protective role for γδ T cells in smokers and suggest ...Continue Reading

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Citations

Sep 5, 2019·The Journal of Clinical Investigation·Matthew C MadisonFarrah Kheradmand
Feb 12, 2019·The Journal of Clinical Investigation·Liza Bronner MurrisonGurjit K Khurana Hershey
Jul 30, 2019·Frontiers in Immunology·Jessica G BorgerMargaret L Hibbs
Feb 15, 2019·Frontiers in Immunology·Myunghoo KimGretchen E Diehl
Dec 25, 2019·Cold Spring Harbor Perspectives in Medicine·Rebekah HonceStacey Schultz-Cherry
Jan 18, 2021·Life Sciences·Sepideh MeidaninikjehReza Jafari
Feb 2, 2021·Frontiers in Immunology·Xiangyun LiXiaoyi Yuan
Mar 15, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nathaniel K BergXiaoyi Yuan
Mar 20, 2021·Science·Zuri A SullivanRuslan Medzhitov
Mar 27, 2021·Frontiers in Immunology·Giulia PiaggeschiAlessia Visconti

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Methods Mentioned

BETA
immune
bronchoalveolar lavage
flow cytometry
enzyme-linked immunosorbent assay
transgenic
ELISA
PCR

Software Mentioned

Graph
GraphPad Prism
FlowJo
- Pad

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