PMID: 11334063May 4, 2001Paper

Protective role of the L-arginine-nitric oxide synthase pathway on preservation injury after rat liver transplantation

JPEN. Journal of Parenteral and Enteral Nutrition
D A GellerN Murase

Abstract

A major problem complicating liver transplantation is the preservation injury that results from cold storage and subsequent ischemia/reperfusion injury after organ revascularization. The L-arginine-nitric oxide (NO) pathway has been recognized to play critical roles during infection, inflammation, organ injury, and transplant rejection. Recent data indicates that NO synthesis has beneficial effects in several models of liver injury. The purpose of this study is to examine the role of the L-arginine-NO pathway on preservation injury in an experimental model of rat liver transplantation. Orthotopic liver transplantation was performed in syngeneic (LEW to LEW) rats. Liver preservation injury was determined by measuring serum liver function tests 6 to 48 hours after transplantation. In some experiments, rats received L-arginine supplementation 0 to 24 hours after transplantation. In other experiments, NO synthase inhibitors (L-NAME or L-NIL) were injected at the time of isograft revascularization. L-Arginine supplementation decreased hepatic transaminase levels at all time points examined (6-48 hours). L-Arginine produced a significant improvement in liver preservation injury by 12 hours after reperfusion. The NO synthase inhibitor...Continue Reading

References

Aug 1, 1992·The Journal of Clinical Investigation·J M LangrehrR A Hoffman
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P KubesD N Granger
Sep 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J C Caldwell-KenkelJ J Lemasters
Aug 1, 1994·The Journal of Clinical Investigation·X YangP J Cannon
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·D J PinskyD M Stern
Jan 1, 1995·The Journal of Experimental Medicine·N K WorrallT B Ferguson
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D A GellerT R Billiar
May 1, 1993·The Journal of Clinical Investigation·B A MarkewitzD E Kohan
Mar 15, 1995·Transplantation·D VillarrealD N Granger
Dec 1, 1995·The Journal of Surgical Research·H KobayashiH Takagi
Feb 1, 1997·Transplantation Proceedings·M FerraressoP Rigotti
May 1, 1997·The Journal of Surgical Research·M ShiraishiY Muto
Oct 23, 1997·The Journal of Clinical Investigation·L L ShearsS M Pham
Apr 17, 1998·Cancer Metastasis Reviews·D A Geller, T R Billiar
Jul 17, 1998·Transplant International : Official Journal of the European Society for Organ Transplantation·J A van der HoevenR J Ploeg
Jan 23, 1999·Journal of the American College of Surgeons·T ShimamuraS Todo
Jul 1, 1999·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·C A BradhamD A Brenner

❮ Previous
Next ❯

Citations

Feb 23, 2008·Molecular Medicine·Andrew J VardanianJerzy W Kupiec-Weglinski
Aug 21, 2015·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Watanabe ToshihiroTakao Ayuse
Dec 21, 2010·Transplantation Proceedings·R Scherer de FragaM R Álvares-da-Silva
Jul 20, 2010·The Surgical Clinics of North America·John R Klune, Allan Tsung
Jun 23, 2009·The Journal of Surgical Research·Rafael Omar GiovanardiAntonio Nocchi Kalil
Jun 20, 2008·Veterinary Surgery : VS·Maximilian M R PolyakAlison J Morton
Sep 23, 2008·BioFactors·Pronobesh ChattopadhyayA K Wahi
Nov 26, 2010·Journal of Hepato-biliary-pancreatic Sciences·Kyota Fukazawa, Ernesto A Pretto
Feb 10, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Mahmoud Abu-AmaraBarry Fuller
Apr 6, 2005·Transplantation Proceedings·D BogettiE Benedetti
Aug 29, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gautam P YagnikDavid A Geller
Jan 7, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Vijay Shah, Patrick S Kamath
Mar 30, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M Morales-RuizW Jiménez
Jul 13, 2005·Clinical Transplantation·Diego BogettiEnrico Benedetti
Oct 7, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kaye M ReidDavid A Geller
Jul 28, 2019·Current Opinion in Organ Transplantation·Parsia A Vagefi
Aug 25, 2020·Current Opinion in Organ Transplantation·Malcolm MacConmaraParsia A Vagefi
Oct 22, 2009·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Shengli WuUrsula Rauen
Nov 18, 2018·Xenotransplantation·Jigesh A ShahParsia A Vagefi
Jun 9, 2019·Xenotransplantation·Nora Hosny, Christopher Burlak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved