Protective role of theophylline and their interaction with nitric oxide (NO) in adjuvant-induced rheumatoid arthritis in rats

International Immunopharmacology
Rishi PalK K Pant

Abstract

Theophylline (non-specific PDE inhibitor) and their interactions with nitric oxide modulators were evaluated in adjuvant-induced arthritic model of rats. Wistar rats (200-300g), 8 animals per group were used in the study. The animals were injected with 0.1mL of squalene and 0.2mL of complete Freund's adjuvant on day (0) in sub-planter region of right hind paw controls received only saline. The treatment with theophylline and nitric oxide modulators were done from day 14 to day 28. Arthritis indexes, ankle diameter, paw volume, and body weight were determined to assess RA progression from day (0) to day 28. On day 28 animals were sacrificed and their blood collected for IL-10 and TNF-α cytokine levels and hind paw for pathological analysis. Synovial fluid from joint spaces of CFA inoculated rats was collected to estimate TNF-α level in synovial fluid. The data obtained was analyzed by two-way ANOVA followed by the Newman-Keuls post-hoc test. Theophylline (10 and 20mg/kg) significantly decreased adjuvant induced increased arthritis-index, paw volume and ankle diameter (p<0.05 in all parameters) compared to only adjuvant control group. It also reversed adjuvant induced slight decrease in body weight to normalcy. l-Arginine 100mg/k...Continue Reading

References

Sep 1, 1989·Cardiovascular Research·B JonzonL Kaijser
Aug 1, 1986·Arthritis and Rheumatism·S J DardickJ D Levine
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D SalveminiP Needleman
Jul 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·J J MascaliL Borish
Mar 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K OhtaH Miyashita
Jan 16, 1998·International Archives of Allergy and Immunology·Y TohdaS Nakajima
Aug 5, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·G R SansoneM Frieri
Oct 29, 1998·General Pharmacology·R M LathaP Varalakshmi
May 20, 1999·Annual Review of Pharmacology and Toxicology·A J HobbsS Moncada
Jun 15, 2000·The American Journal of Pathology·B C CarlsonJ C Lorentzen
Feb 13, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·E BeshayG J Prud'homme
Sep 25, 2001·Lancet·D M Lee, M E Weinblatt
May 11, 2002·The Tohoku Journal of Experimental Medicine·Minka YoshikawaTetsuya Takayanagi
Mar 20, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Omar M E Abdel-SalamMahmoud S Arbid
Aug 1, 1963·British Journal of Pharmacology and Chemotherapy·B B NEWBOULD
Oct 17, 2003·Current Drug Targets. Inflammation and Allergy·M MarkovicV Trajkovic
Mar 5, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jae Youl ChoMyung Hwan Park
Apr 9, 2010·International Journal of Rheumatic Diseases·Pallinti VasanthiG Rajasekhar

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