Protective role of vitamin E on the microcystin-induced oxidative stress in tilapia fish (Oreochromis niloticus)

Environmental Toxicology and Chemistry
Ana I PrietoAna M Cameán

Abstract

Microcystins (MCs) are potent hepatotoxins produced by cyanobacteria in water systems that induce oxidative stress in fish. The present study investigated the effect of vitamin E pretreatment on MC-induced oxidative damage in the liver, kidneys, and gills of tilapia fish (Oreochromis niloticus). Groups of fish were fed vitamin E supplements (200 or 700 mg per kilogram of diet) for 7 d or received only commercial fish food and then were exposed to a single oral dose of cyanobacterial cells (120 microg of MC-LR [2:Leu, 4:Arg] per fish), and were sacrificed in 24 h. The potential benefits of vitamin E were evaluated based on lipid peroxidation (LPO), protein oxidation, catalase (CAT, Enzyme Commission [EC] 1.11.1.6), superoxide dismutase (EC 1.15.1.1), glutathione peroxidase (EC 1.11.1.9), glutathione reductase (EC 1.8.1.7), and the ratio of reduced glutathione to oxidized glutathione (GSH/GSSG). Microcystins induced a 1.6-fold increase in LPO values in liver, whereas vitamin E-pretreated fish showed no alteration on this biomarker. Enzyme activities levels were also ameliorated by the chemoprotectant, whereas protein oxidation and GSH/GSSG did not show any significant change. The higher vitamin E dose used proved to have the grea...Continue Reading

Citations

Jul 7, 2012·Environmental Science and Pollution Research International·Hana PaskerováLuděk Bláha
Feb 18, 2010·International Journal of Molecular Sciences·Alexandre Campos, Vitor Vasconcelos
Apr 19, 2012·Environmental Toxicology and Chemistry·Daniel Gutiérrez-PraenaAna M Cameán
Aug 4, 2015·Toxicon : Official Journal of the International Society on Toxinology·Remedios Guzmán-GuillénAna M Cameán
May 19, 2011·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Lílian L AmadoJosé M Monserrat
Dec 4, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Daniel Gutiérrez-PraenaAna M Cameán
Mar 21, 2017·Fish Physiology and Biochemistry·Xiu-Mei ChenDong-Ming Zhang
May 27, 2017·Toxins·Remedios Guzmán-GuillénAna M Cameán
Nov 5, 2020·Toxins·Shuaishuai XuLi Tian
Mar 2, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Zhuoyu WangJingxiang Zhou
Jul 3, 2020·Chemical Research in Toxicology·Celine M SchreidahAjith Karunarathne

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