Protective roles of B and T lymphocyte attenuator in NKT cell-mediated experimental hepatitis

The Journal of Immunology : Official Journal of the American Association of Immunologists
Arifumi IwataHiroshi Nakajima

Abstract

Although B and T lymphocyte attenuator (BTLA) was originally identified as an inhibitory coreceptor selectively expressed on Th1 cells and B cells, recent studies have revealed that BTLA is expressed on a variety of cells, including macrophages, dendritic cells, and NK cells, and modulates their functions. However, the role of BTLA in the regulation of NKT cell function remains unknown. In this study, we found that BTLA was expressed on NKT cells at the levels similar to those on T cells and that BTLA-deficient (BTLA(-/-)) NKT cells produced larger amounts of IL-4 and IFN-gamma upon alpha-glactosylceramide stimulation as compared with wild-type (WT) NKT cells. In vivo, BTLA(-/-) mice produced larger amounts of IL-4 and IFN-gamma upon Con A injection and were more susceptible to Con A-induced hepatitis than WT mice. In addition, the augmentation of Con A-induced hepatitis in BTLA(-/-) mice was not observed in BTLA/NKT-double deficient mice. Moreover, NKT(-/-) mice reconstituted with BTLA(-/-) NKT cells were significantly more susceptible to Con A-induced hepatitis as compared with NKT (-/-) mice reconstituted with WT NKT cells. These results suggest that BTLA functions as the inhibitory coreceptor of NKT cells and plays a critic...Continue Reading

References

Jul 1, 1992·The Journal of Clinical Investigation·G TiegsA Wendel
Jun 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H LouisJ Devière
May 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·K TakedaK Okumura
Jan 25, 2003·Annual Review of Immunology·Masaru TaniguchiHiroshi Wakao
May 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maureen N AjueborMark G Swain
Jun 11, 2003·Nature Immunology·Norihiko WatanabeKenneth M Murphy
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peggy HanJonathan Kaye
Jan 5, 2005·Biochemical and Biophysical Research Communications·Hiroshi KanedaKo Okumura
Jan 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Lino C GonzalezDan L Eaton
Mar 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michelle A HurchlaKenneth M Murphy
Mar 18, 2005·Annual Review of Immunology·Tania H Watts
Mar 18, 2005·Annual Review of Immunology·Rebecca J GreenwaldArlene H Sharpe
Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ran TaoWayne W Hancock
Mar 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christine DeppongJonathan M Green
Mar 25, 2006·The Journal of Clinical Investigation·Sudarshan AnandKoji Tamada
Aug 26, 2006·Nature Reviews. Immunology·Kenneth M MurphyJohn R Sedý
Aug 9, 2007·International Archives of Allergy and Immunology·Tomohiro TamachiHiroshi Nakajima
Jan 15, 2008·Nature Protocols·Hiroshi WataraiMasaru Taniguchi
Jun 4, 2008·The Journal of Experimental Medicine·Marcos W SteinbergMitchell Kronenberg
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Woo-Sung ChangChang-Yuil Kang
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hua-Xing WeiZhigang Tian
Dec 26, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Toshihiko KawamuraMark J Smyth
May 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jianxiong WangYang Yang
Jun 19, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mendy L MillerYang-Xin Fu
Jul 2, 2009·Journal of Leukocyte Biology·Alison Crawford, E John Wherry

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Citations

Mar 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yoshihisa KobayashiHiroshi Nakajima
Dec 2, 2010·International Immunology·Tomonori IyodaKayo Inaba
Nov 26, 2010·Journal of Leukocyte Biology·Jr-Wen ShuiMitchell Kronenberg
Sep 22, 2012·Clinical & Developmental Immunology·Norihiko Watanabe, Hiroshi Nakajima
Feb 26, 2015·The Journal of Experimental Medicine·Tony C TuYang-Xin Fu
Mar 1, 2016·Cellular & Molecular Immunology·Jose-Ignacio Rodriguez-BarbosaMaria-Luisa Del Rio
Mar 10, 2018·International Journal of Molecular Sciences·Divya SekarAndreas Weigert
May 8, 2019·Cancers·Sebastian ChrétienTheodoros Foukakis
Nov 26, 2013·The Cancer Journal·Tomasz MajWeiping Zou
Nov 23, 2019·Journal for Immunotherapy of Cancer·Yu-Li ChenWen-Fang Cheng
Jul 25, 2019·Nature Communications·Tae-Jin KimKyung-Mi Lee
Nov 23, 2017·Frontiers in Immunology·Susannah C ShisslerTonya J Webb
Apr 16, 2019·Frontiers in Immunology·Xueping YuJiming Zhang
Oct 25, 2011·Immunological Reviews·Marcos W SteinbergCarl F Ware
Sep 29, 2017·Current Allergy and Asthma Reports·Anna S Tocheva, Adam Mor
Oct 29, 2021·The Journal of Experimental Medicine·Weifeng LiuSteven C Almo

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