Protective Roles of Natural IgM Antibodies.

Frontiers in Immunology
Caroline GrönwallGregg J Silverman

Abstract

Antibodies are a vital part of the armamentarium of the adaptive immune system for the fine-tuning of the recognition and response to foreign threats. However, in health there are some types of antibodies that instead recognize self-antigens and these contribute to the enhancement of primitive innate functions. This repertoire of natural IgM antibodies is postulated to have been selected during immune evolution for their contributions to critical immunoregulatory and housekeeping properties. The clearance of dying cells is one of the most essential responsibilities of the immune system, which is required to prevent uncontrolled inflammation and autoimmunity. In the murine immune system, natural IgM antibodies that recognize apoptotic cells have been shown to enhance the phagocytic clearance of dead and dying cells and to suppress innate immune signaling pathways. In the mouse, natural IgM are often the products of B-1 cell clones that arise during immune development without an absolute requirement for exogenous antigenic stimulation. In patients with systemic lupus erythematosus, IgM autoantibodies, which bind to neo-epitopes on apoptotic cells, have been demonstrated to be present at significantly higher levels in patients wit...Continue Reading

Citations

Oct 9, 2013·Nature Reviews. Rheumatology·Aikaterini Thanou, Joan T Merrill
Apr 25, 2014·PloS One·Caroline GrönwallGregg J Silverman
Dec 11, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Malcolm Buckle
Feb 13, 2016·Immunological Reviews·J Stewart NewJohn F Kearney
Jan 6, 2016·Parasite Immunology·Gustavo Mourglia-EttlinSylvia Dematteis
Jul 7, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Trisha A RettigSherry D Fleming
Aug 21, 2015·Annals of the New York Academy of Sciences·Rebecca A LeeXuemei Zhong
May 17, 2015·Journal of Proteomics·Akio KimuraTakashi Inuzuka
Apr 6, 2016·Frontiers in Immunology·Nichol E HolodickLaurence Morel
Apr 12, 2015·Biochemical and Biophysical Research Communications·Jingang AnJianwen Ren
Jul 17, 2013·Journal of Vascular Surgery·Michael SobelEvercita Eugenio
Jun 22, 2014·The Veterinary Journal·Elliott R JacobsonKristin H Berry
Jun 12, 2013·Journal of Immunotoxicology·Jean C PfauRyan Marcum
Apr 14, 2015·Future Microbiology·Soma Rohatgi, Liise-Anne Pirofski
Feb 14, 2015·Future Neurology·Xiaohua XuMoses Rodriguez
Apr 16, 2014·Frontiers in Immunology·Nichol E HolodickThomas L Rothstein
May 2, 2014·Frontiers in Immunology·Elmar Pieterse, Johan van der Vlag
Dec 3, 2014·Reumatología clinica·Olga Sánchez-Pernaute
Jun 19, 2016·Biochemical and Biophysical Research Communications·Kyung Oh JungJune-Key Chung
Jul 8, 2016·Asian-Australasian Journal of Animal Sciences·Shen XingGuanghong Zhou
Feb 6, 2017·Scientific Reports·Elisabet AugéJordi Vilaplana
Jul 7, 2017·Infectious Diseases·Christine WenneråsAnders Rosén
Jun 18, 2017·Molecular Immunology·Aleksei KrasnovSergey Afanasyev

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
MDA

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.