Protective to a T: The Role of T Cells during Zika Virus Infection

Cells
Ryan D Pardy, Martin J Richer

Abstract

CD4 and CD8 T cells are an important part of the host's capacity to defend itself against viral infections. During flavivirus infections, T cells have been implicated in both protective and pathogenic responses. Given the recent emergence of Zika virus (ZIKV) as a prominent global health threat, the question remains as to how T cells contribute to anti-ZIKV immunity. Furthermore, high homology between ZIKV and other, co-circulating flaviviruses opens the possibility of positive or negative effects of cross-reactivity due to pre-existing immunity. In this review, we will discuss the CD4 and CD8 T cell responses to ZIKV, and the lessons we have learned from both mouse and human infections. In addition, we will consider the possibility of whether T cells, in the context of flavivirus-naïve and flavivirus-immune subjects, play a role in promoting ZIKV pathogenesis during infection.

References

Jan 6, 2000·Transgenic Research·B E ClausenI Förster
Sep 1, 1952·Transactions of the Royal Society of Tropical Medicine and Hygiene·G W A DICKA J HADDOW
Sep 1, 1952·Transactions of the Royal Society of Tropical Medicine and Hygiene·G W A DICK
Dec 4, 2003·Journal of Virology·Yang WangArno Müllbacher
Oct 12, 2004·Nature Immunology·Christopher M SmithGabrielle T Belz
Sep 1, 2005·The Journal of Experimental Medicine·Ganesh A KolumamKaja Murali-Krishna
Sep 13, 2006·Journal of Neurovirology·Ellen GelpiHerbert Budka
Jun 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·João A Pedras-VasconcelosDaniela Verthelyi
Dec 17, 2008·Virology·Daniel RůzekLibor Grubhoffer
Jun 12, 2009·The New England Journal of Medicine·Mark R DuffyEdward B Hayes
Apr 7, 2010·Current Opinion in Immunology·Julie M Curtsinger, Matthew F Mescher
Jul 3, 2010·Current Opinion in Immunology·J S M PeirisHui-Ling Yen
Sep 21, 2011·The Journal of Experimental Medicine·Mark S DiamondRobert D Schreiber
Apr 5, 2012·Clinical & Developmental Immunology·Rishi Vishal LuckheeramBing Xia
Mar 15, 2014·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·E OehlerF Ghawche
Dec 30, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria R BassiAllan R Thomsen
Dec 22, 2015·Cytokine·Stefanie F ValbonMartin J Richer
Mar 30, 2016·The American Journal of Tropical Medicine and Hygiene·Shannan L RossiScott C Weaver
Apr 14, 2016·Cell Host & Microbe·Helen M LazearMichael S Diamond
May 7, 2016·PLoS Neglected Tropical Diseases·Stuart D DowallRoger Hewson
Sep 11, 2016·Cell Reports·Jonathan J MinerRajendra S Apte
Oct 6, 2016·ACS Infectious Diseases·Maaran M RajahSelena M Sagan
Oct 7, 2016·Bulletin of the World Health Organization·Mary Kay KindhauserChristopher Dye
Jan 4, 2017·PLoS Medicine·Fabienne KrauerUNKNOWN WHO Zika Causality Working Group
Jan 13, 2017·Cell Host & Microbe·Annie Elong NgonoSujan Shresta
Mar 24, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Clayton W WinklerKarin E Peterson
Jul 14, 2017·Open Forum Infectious Diseases·Jesse J WaggonerMark J Mulligan
Aug 2, 2017·Open Forum Infectious Diseases·Srilatha EdupugantiMark J Mulligan
Aug 25, 2017·Journal of Virology·Huarong HuangFuping Zhang
Aug 25, 2017·Pathogens & Immunity·Dominic Paquin-ProulxDouglas F Nixon
Oct 6, 2017·Journal of Virology·Alba GrifoniAlessandro Sette
Oct 12, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lilin LaiUNKNOWN Emory Zika Patient Study Team
Nov 22, 2017·Nature Microbiology·Kellie A JuradoAkiko Iwasaki
Dec 29, 2017·Immunity, Inflammation and Disease·Jessica Badolato-CorrêaLuzia Maria de-Oliveira-Pinto
Jan 19, 2018·Journal of Virology·Jason M ScottHaina Shin

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Citations

Nov 30, 2019·Immunology·Alba GrifoniDaniela Weiskopf
Jul 30, 2020·Journal of Leukocyte Biology·Tertuliano Alves Pereira NetoHelton da Costa Santiago
Aug 5, 2020·Scientific Reports·Blake SchouestNicholas J Maness
Jan 2, 2021·Frontiers in Pediatrics·Tulika SinghSallie R Permar
Oct 30, 2020·Frontiers in Immunology·Elaine L ParkerIndira U Mysorekar
Mar 9, 2021·Frontiers in Immunology·Jessica Badolato-CorrêaLuzia Maria de-Oliveira-Pinto

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