Protein acetylation: an important mechanism in actinobacteria

Bioscience Reports
Huaidong Zhang, Ximing Xu

Abstract

This is a commentary on the research article by Lu et al. recently published in Bioscience Reports The GCN5-like acetyltransferases with amino acid-binding (ACT)-GCN5-related N-acetyltransferase (GNAT) domain organization have been identified in actinobacteria by Lu et al. (2017). The ACT domain is fused to the GNAT domain, conferring amino acid-induced allosteric regulation to these protein acetyltransferases (Pat) (amino acid sensing acetyltransferase (AAPatA)). Members of the AAPatA family share similar secondary structure and are divided into two groups based on the allosteric ligands of the ACT domain: the asparagine (Asn)-activated PatA and the cysteine (Cys)-activated PatA. The former are mainly found in Streptomyces; the latter are distributed in other actinobacteria. The authors investigated the effect of Asn and Cys on the acetylation activity of Sven_0867 (SvePatA, from Streptomyces venezuelae DSM 40230) and Amir_5672 (AmiPatA, from Actinosynnema mirum strain DSM 43827), respectively, as well as the relationship between the structure and function of these enzymes. Research history and progress on acetyltransferases and lysine acetylation of proteins were discussed. The activity of PatA and acetylation level of protei...Continue Reading

References

Jul 9, 2004·Journal of Molecular Biology·Vincent J Starai, Jorge C Escalante-Semerena
Sep 24, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Xiang-Jiao Yang
Oct 8, 2004·The Journal of Biological Chemistry·Qiyuan LiuJin Q Cheng
May 29, 2010·The Journal of Biological Chemistry·Subhalaxmi NambiSandhya S Visweswariah
Jun 16, 2011·Proteomics·Joshua D Jones, C David O'Connor

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Methods Mentioned

BETA
acylation
acetylation
chip

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