Protein Adsorption and Coordination-Based End-Tethering of Functional Polymers on Metal-Phenolic Network Films

Biomacromolecules
Blaise L TardyFrank Caruso

Abstract

Metal-phenolic network (MPN) coatings have generated increasing interest owing to their biologically inspired nature, facile fabrication, and near-universal adherence, especially for biomedical applications. However, a key issue in biomedicine is protein fouling, and the adsorption of proteins on tannic acid-based MPNs remains to be comprehensively studied. Herein, we investigate the interaction of specific biomedically relevant proteins in solution (e.g., bovine serum albumin (BSA), immunoglobulin G (IgG), fibrinogen) and complex biological media (serum) using layer-by-layer-assembled tannic acid/FeIII MPN films. When FeIII was the outermost layer, galloyl-modified poly(2-ethyl-2-oxazoline) (P(EtOx)-Gal) could be grafted to the films through coordination bonds. Protein fouling and bacterial adhesion were greatly suppressed after functionalization with P(EtOx)-Gal and the mass of adsorbed protein was reduced by 79%. Interestingly, larger proteins adsorbed more on both the MPNs and P(EtOx)-functionalized MPNs. This study provides fundamental information on the interactions of MPNs with single proteins, mixtures of proteins as encountered in serum, and the noncovalent, coordination-based, functionalization of MPN films.

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Citations

Feb 29, 2020·Research and Practice in Thrombosis and Haemostasis·Karl Ewins, Fionnuala Ní Ainle
Feb 18, 2021·Chemical Society Reviews·Di WuJesse V Jokerst
Mar 18, 2021·Biomaterials Science·Lucca TrachselEdmondo M Benetti
Mar 11, 2021·Biomaterials Science·Peng LiuWenhu Zhou
Jun 10, 2021·Scientific Reports·Shella Permatasari SantosoYi-Hsu Ju
Aug 27, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Seulbi KimJi Hun Park
Jan 22, 2022·Langmuir : the ACS Journal of Surfaces and Colloids·Yohan KimSung Min Kang
Jan 22, 2022·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Gnanasekar SathishkumarYunlong Yu

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