Protein adsorption and endothelial cell attachment and proliferation on PAPI-based additive modified poly(ether urethane ureas)

Journal of Biomedical Materials Research
M R BrunstedtJ M Anderson

Abstract

To better understand vascular interactions with poly(ether urethane urea) (PEUU) materials, protein adsorption, and endothelial cell attachment and proliferation assays were performed on a base PEUU formulation, on PEUU formulations loaded with hydrophobic and amphiphilic poly(methylene-[polyphenyl isocyanate]) (PAPI) based additives, and on PEUU formulations in which some of the polymer chains had been endcapped with either diisopropylaminoethyl (DIPAA) or decyl (DA) moieties. Protein adsorption experiments with PAPI-based additives showed that additive loaded PEUU formulations adsorbed significantly lower amounts of the studied proteins than did the unloaded PEUU. Protein adsorption to the DA and DIPAA endcapped PEUU films was found not to vary consistently from that of the unloaded PEUU film. Endothelial cell attachment and proliferation experiments with PAPI-DA and polyethylene glycol-PAPI-DA (PEG-PAPI-DA) loaded PEUU films showed that many of the films exhibited attachment and proliferation that was significantly enhanced compared to PEUU A' and that approached or equaled that of the tissue culture polystyrene control. Experiments with PAPI-DIPAA and PEG-PAPI-DIPAA loaded PEUU films exhibited attachment and proliferation d...Continue Reading

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Citations

Mar 5, 2003·Biomaterials·Gabriela VoskericianRobert Langer
Mar 31, 2005·Journal of Biomaterials Science. Polymer Edition·Sachiko InoueYasuhiko Tabata
Jan 1, 1996·Journal of Biomaterials Science. Polymer Edition·V V NikolaychikP I Lelkes
Nov 16, 2011·Journal of Biomedical Materials Research. Part a·Dongsheng TanQiang Fu

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