PMID: 8957706Jan 1, 1996Paper

Protein adsorption and platelet adhesion on polymer surfaces having phospholipid polar group connected with oxyethylene chain

Journal of Biomaterials Science. Polymer Edition
Y IwasakiN Nakabayashi

Abstract

We evaluated the blood compatibility of various amphiphilic polymers, that is, n-butyl methacrylate (BMA) copolymers with methacrylates having a phosphorylcholine (PC), hydroxy (OH) or methoxy (MeO) group as an end polar group in the oxyethylene side chain. The amount of proteins adsorbed on the PC-polymer from human plasma was smaller than that on not only the poly(2-hydroxyethyl methacrylate) and poly(methyl methacrylate) but also the OH-polymer and MeO-polymer. The PC group could weaken the interaction between plasma proteins and polymer surfaces. The amount of adsorbed proteins on the PC-polymer decreased with an increase in the mole fraction of the PC units in the polymers. We could observe an effect of the oxyethylene chain length (n is the number of repeating units of oxyethylene) on protein adsorption between n = 2 and n = 3. The platelet adhesion on these polymer surfaces was evaluated using rabbit platelet-rich plasma. On the polymers without the PC group, that is, poly(BMA), OH-polymer, and MeO-polymer, many platelets adhered and a considerable shape change in the adherent platelets occurred. On the other hand, the PC-polymers could effectively suppress platelet adhesion. The platelet adhesion behavior on the polymer...Continue Reading

References

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Citations

Dec 19, 2002·Cell Communication & Adhesion·Gurunathan MurugesanKandice Kottke-Marchant
Dec 24, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Oraphan WiarachaiVoravee P Hoven
May 8, 2003·Journal of Biomedical Materials Research. Part a·Yasuhiko IwasakiNobuo Nakabayashi
Dec 11, 1999·Journal of Biomaterials Science. Polymer Edition·D LeckbandA Halperin
Feb 22, 2005·Analytical and Bioanalytical Chemistry·Yasuhiko Iwasaki, Kazuhiko Ishihara
Aug 28, 2001·Journal of Biomedical Materials Research·S SagnellaK Kottke-Marchant
May 23, 1998·Journal of Biomedical Materials Research·J N Baumgartner, S L Cooper
Feb 26, 2003·Journal of Biomedical Materials Research. Part a·Ann-Sofie AnderssonBengt Kasemo
May 11, 2011·Biomacromolecules·Sophie MongeJean-Jacques Robin
Oct 7, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Xiubo ZhaoJian R Lu

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