Protein aggregation - Mechanisms, detection, and control

International Journal of Pharmaceutics
Wei Wang, Christopher J Roberts

Abstract

Protein aggregation has been recognized as one of the major challenges in the development and commercialization of successful protein-based drug products because of the inherent and high aggregation tendency during various manufacturing processes, storage, and administration. Protein aggregates may impact significantly the product quality, safety and/or efficacy. This review is intended to summarize four major aspects of protein aggregation - (1) aggregation mechanisms, (2) aggregation-influencing factors, (3) detection of protein aggregates, and (4) control of protein aggregation based on recent literature in this area.

Citations

May 23, 2020·Scientific Reports·Kyoung SongYoung Kee Shin
Sep 6, 2020·Biomolecules·Shakiba NikfarjamTaylor J Woehl
Jun 13, 2020·Cellular and Molecular Neurobiology·Shusheng Wu, Longfei Du
Mar 20, 2020·International Journal of Molecular Sciences·Valeriya V MikhaylovaBoris I Kurganov
Oct 30, 2020·Pharmaceutics·Wanling LiangJenny K W Lam
Sep 20, 2019·Colloids and Surfaces. B, Biointerfaces·Hugo Cunha-SilvaM Julia Arcos-Martinez
Aug 31, 2020·Trends in Biotechnology·Ali Akbar Ashkarran, Morteza Mahmoudi
Feb 26, 2020·Protein and Peptide Letters·Noriyuki Shiraishi, Yoshiaki Hirano
Mar 22, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ruben WälchliPaolo Arosio
Mar 1, 2021·Journal of Pharmaceutical Sciences·Juan P Rincon PabonDavid D Weis
Apr 2, 2021·The EMBO Journal·Maria Elena CicardiDavide Trotti
May 31, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Marieke E Klijn, Jürgen Hubbuch
Jun 22, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Adam J S McCartanRandall J Mrsny
Jun 14, 2021·Biophysical Chemistry·Gulsum MericChristopher J Roberts
Jul 13, 2021·The Journal of Physical Chemistry. B·Beata Szała-Mendyk, Andrzej Molski
Jul 27, 2021·Advanced Healthcare Materials·Eduard TrenkenschuhWolfgang Friess
Aug 13, 2021·Pharmaceutical Research·Shrenik MehtaAlavattam Sreedhara
Sep 17, 2021·Pharmaceutical Research·Thomas PowellWilliam Burkitt
Sep 22, 2021·International Journal of Pharmaceutics·Ashutosh SharmaHelen Hughes
Nov 23, 2021·PloS One·Austin RoysterMohammad Ayoub Mir
Jan 31, 2022·Journal of Pharmaceutical Sciences·Tapan K DasPaolo Arosio

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Pharmaceutics
Wei WangDirk Teagarden
Ceská a Slovenská farmacie : casopis Ceské farmaceutické spolecnosti a Slovenské farmaceutické spolecnosti
Andrej Murányi, Mária Vitková
© 2022 Meta ULC. All rights reserved