Protein Aggregation in the Pathogenesis of Ischemic Stroke.

Cellular and Molecular Neurobiology
Shusheng Wu, Longfei Du

Abstract

Despite the distinction between ischemic stroke and neurodegenerative disorders, they share numerous pathophysiologies particularly those mediated by inflammation and oxidative stress. Although protein aggregation is considered to be a hallmark of neurodegenerative diseases, the formation of protein aggregates can be also induced within a short time after cerebral ischemia, aggravating cerebral ischemic injury. Protein aggregation uncovers a previously unappreciated molecular overlap between neurodegenerative diseases and ischemic stroke. Unfortunately, compared with neurodegenerative disease, mechanism of protein aggregation after cerebral ischemia and how this can be averted remain unclear. This review highlights current understanding on protein aggregation and its intrinsic role in ischemic stroke.

References

Sep 27, 2000·Journal of Neuropathology and Experimental Neurology·D CadavidR A Frommelt
Jun 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·A AlonsoK Iqbal
Jul 4, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B R HuC L Liu
Nov 9, 2004·Nature·Richard I GregoryRamin Shiekhattar
Jun 28, 2006·International Journal of Geriatric Psychiatry·Mattias HaglundElisabet Englund
Aug 24, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Donald J DeGracia, Bingren R Hu
Nov 23, 2006·Biochimica Et Biophysica Acta·Yi WenJames W Simpkins
Nov 3, 2007·Stroke; a Journal of Cerebral Circulation·Pengfei GeBingren Hu
Jan 19, 2008·Stroke; a Journal of Cerebral Circulation·Joachim Röther
Oct 7, 2008·Annual Review of Pharmacology and Toxicology·Alan L Schwartz, Aaron Ciechanover
Jul 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Eunsung JunnM Maral Mouradian
Sep 4, 2009·Brain Pathology·Virawudh SoontornniyomkijHarry V Vinters
Nov 28, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ryszard PlutaMirosław Jabłoński
Aug 17, 2010·PLoS Biology·Della C DavidCynthia Kenyon
Dec 7, 2010·The EMBO Journal·Youhna M AyalaFrancisco E Baralle
Jan 27, 2011·Methods in Enzymology·Stefano ToldoAlfonso Baldi
Sep 10, 2011·Behavioural Brain Research·Anjali ChauhanYogendra Kumar Gupta
Nov 8, 2011·Journal of Neurology, Neurosurgery, and Psychiatry·Andreas CharidimouDavid J Werring
Apr 21, 2012·Journal of Pharmaceutical Sciences·Vasco FilipeWim Jiskoot
May 30, 2012·Journal of Neurochemistry·George StoicaIan Murray
Jun 2, 2012·Autophagy·Peter G H Clarke, Julien Puyal
Jun 16, 2012·Stroke; a Journal of Cerebral Circulation·Karin HochrainerCostantino Iadecola
Oct 2, 2012·Cell Reports·Tomohiro YamazakiRobin Reed
Dec 21, 2012·Nature Reviews. Neuroscience·Hilal A LashuelEliezer Masliah
Dec 21, 2012·EMBO Molecular Medicine·Hitomi TsuijiKoji Yamanaka
May 16, 2013·Acta Neuropathologica·Anna M BlokhuisR Jeroen Pasterkamp

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