Protein and amino acid metabolism in the human newborn

Annual Review of Nutrition
Satish C Kalhan, Dennis M Bier

Abstract

Birth and adaptation to extrauterine life involve major shifts in the protein and energy metabolism of the human newborn. These include a shift from a state of continuous supply of nutrients including amino acids from the mother to cyclic periodic oral intake, a change in the redox state of organs, thermogenesis, and a significant change in the mobilization and use of oxidative substrates. The development of safe, stable isotopic tracer methods has allowed the study of protein and amino acid metabolism not only in the healthy newborn but also in those born prematurely and of low birth weight. These studies have identified the unique and quantitative aspects of amino acid/protein metabolism in the neonate, thus contributing to rational nutritional care of these babies. The present review summarizes the contemporary data on some of the significant developments in essential and dispensable amino acids and their relationship to overall protein metabolism. Specifically, the recent data of kinetics of leucine, phenylalanine, glutamine, sulfur amino acid, and threonine and their relation to whole-body protein turnover are presented. Finally, the physiological rationale and the impact of nutrient (amino acids) interventions on the dyna...Continue Reading

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Citations

Mar 28, 2012·Amino Acids·Zhao-Lai DaiWei-Yun Zhu
Mar 16, 2012·Reviews in Endocrine & Metabolic Disorders·Satish C Kalhan, Susan E Marczewski
Apr 1, 2013·Journal of Developmental Origins of Health and Disease·S C Kalhan, D Wilson-Costello
Nov 27, 2009·The American Journal of Clinical Nutrition·Jaividhya DasarathySatish C Kalhan
Mar 5, 2016·Nutrition Reviews·Dominique Meynial-Denis
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Jun 9, 2016·Molecular and Cellular Endocrinology·Satish C Kalhan
Apr 12, 2017·Antioxidants & Redox Signaling·Roberta d'Emmanuele di Villa BiancaRaffaella Sorrentino
Sep 22, 2015·PloS One·Ernesto Cortés-CastellVicente Francisco Gil-Guillén
Dec 21, 2018·Drug Metabolism and Disposition : the Biological Fate of Chemicals·April Neal-KlueverWendy Halpern
Jan 4, 2020·Journal of Pediatric Gastroenterology and Nutrition·Qiqi RenWei Zhang
Apr 25, 2013·Journal of Pediatric Endocrinology & Metabolism : JPEM·Yingzhong HeXinshun Zhang
Sep 15, 2020·Scandinavian Journal of Clinical and Laboratory Investigation·Penelope D Manta-VogliYannis Dotsikas
Aug 23, 2017·Annual Review of Nutrition·Dennis M Bier
Feb 12, 2017·The Journal of Cell Biology·Désirée SchattonElena I Rugarli
Nov 24, 2020·Molecular Nutrition & Food Research·Shuang CaiShiyan Qiao

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