PMID: 2122015Sep 1, 1990Paper

Protein and energy metabolism with biosynthetic human growth hormone in patients on full intravenous nutritional support

JPEN. Journal of Parenteral and Enteral Nutrition
G A PontingA J Sim

Abstract

Our objective was to examine the effect of biosynthetic human growth hormone (BSHGH) on protein and energy metabolism in patients on full intravenous nutrition (IVN). Fifteen patients who had been established on IVN were allocated at random to receive either BSHGH (0.1 mg/kg/day) or placebo daily for 7 days. All patients received the same feeding regimen which contaminated 14 gN, 1000 kcal of glucose and 1000 kcal of fat (Intralipid) daily. The mean nitrogen balance for days 4 to 7 was significantly more positive with BSHGH (7.0 +/- 0.6 gN/day) than with placebo (4.4 +/- 0.7 gN/day). The BSHGH group were lighter (53 +/- 4.6 kg body weight) than controls (68 +/- 5.1 kg), but the difference was not significant. Resting energy expenditure (expressed as percentage of day 1) increased throughout the study in patients receiving BSHGH (day 7, 120.8 +/- 5.5%), whereas in patients receiving placebo it remained stable (day 7, 98.9 +/- 2.7%). The nonprotein respiratory quotients were similar for BSHGH (mean days 4-7, 0.94 +/- 0.04) and placebo (mean days 4-7, 0.93 +/- 0.01) (p greater than 0.05). This study demonstrates more positive nitrogen balance, which may in part be due to different substrate loads, and an increase in energy expendi...Continue Reading

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Citations

Jun 1, 1992·Irish Journal of Medical Science·D J Hehir, T F Gorey
Nov 5, 2003·Frontiers in Neuroendocrinology·Massimo ScacchiFrancesco Cavagnini
Oct 1, 1996·Baillière's Clinical Endocrinology and Metabolism·A M Umpleby, D L Russell-Jones
Jan 1, 1993·Nutrition Research Reviews·G K Grimble
Nov 9, 1991·BMJ : British Medical Journal·R J RossC R Buchanan
Jan 12, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·P V Carroll
Jan 22, 2002·Best Practice & Research. Clinical Endocrinology & Metabolism·P V Carroll
Feb 1, 1992·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·M S Dahn
Mar 1, 1995·JPEN. Journal of Parenteral and Enteral Nutrition·M JeevanandamS R Petersen
Feb 1, 1996·Anesthesia and Analgesia·N MertesJ F Zander
Jul 18, 2001·Current Opinion in Clinical Nutrition and Metabolic Care·C A RagusoC Pichard
Feb 15, 2002·Current Opinion in Clinical Nutrition and Metabolic Care·Esko Ruokonen, Jukka Takala
May 22, 2003·American Journal of Physiology. Endocrinology and Metabolism·Paul V CarrollA Margot Umpleby

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