PMID: 8613894Apr 1, 1996Paper

Protein and lipid refeeding changes protein metabolism and colonic but not small intestinal morphology in protein-depleted rats

The Journal of Nutrition
Z QuB R Bistrian

Abstract

In this study, we fed rats a 2% casein AIN 76 diet for 2 wk to produce protein malnutrition. We determined in these animals the effects of different concentrations of dietary protein refeeding (2% and 20% casein) on recovery and gut mucosal repletion and the potential role of type of dietary fat in the regulation of protein metabolism and mucosal growth by providing conventional long-chain triglyceride (LCT), a structured lipid composed of long-, medium- and short-chain fatty acids (SC/SL), or a physical mixture of the same components present in the structured lipid given as individual pure triglycerides (SC/PM) along with adequate amounts of protein and energy. The results confirmed that protein malnutrition can be reversed rapidly by protein refeeding, as indicated by an increase in body weight, positive nitrogen balance, liver growth and elevations in plasma concentrations of insulin-like growth factor-1, leucine and albumin. In the colon, crypt cell number, crypt depth and number of crypt cells in the rapidly proliferating fraction of the colon were greater in rats fed the higher protein diet. However, the general architecture of small intestinal mucosa, including duodenum, jejunum and ileum, was not affected by protein mal...Continue Reading

Citations

Sep 17, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Pei-Ra LingBruce R Bistrian
Feb 4, 2011·The Journal of Veterinary Medical Science·Akihiko SugiyamaTakashi Takeuchi

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