Protein and mRNA expression of uPAR and PAI-1 in myoepithelial cells of early breast cancer lesions and normal breast tissue

British Journal of Cancer
Ralf Hildenbrand, N Arens

Abstract

Myoepithelial cells (MEs), which surround ducts and acini of the breast glands, exhibit an anti-invasive phenotype and form a natural border separating proliferating tumour cells of ductal carcinoma in situ (DCIS) from basement membrane (bm) and underlying stroma. Invasion requires penetration of these host cellular and extracellular matrix barriers. This destruction is caused by proteolytic activity of tumour cells and host bystander cells. There is substantial evidence that high concentrations of the urokinase plasminogen-activating system are conducive to tumour cell spread and metastasis. Prompted by the conspicuous absence of studies examining the role of the ME in breast cancer progression, we studied the expression of the urokinase plasminogen activator receptor (uPAR) and plasminogen activator inhibitor type-1 (PAI-1) in MEs of 60 DCIS samples. Our results show that nearly all MEs of DCIS and normal breast glands exhibit the uPAR antigen, whereas the PAI-1 antigen was mainly expressed in MEs of high-grade DCIS. In one intermediate DCIS numerous ducts showed an incomplete myoepithelial layer expressing uPAR and PAI-1. We conclude that uPAR in MEs may be necessary to attach them to the bm by uPAR/vitronectin (Vn) interact...Continue Reading

References

Dec 1, 1986·The Journal of Clinical Investigation·D GinsburgT D Gelehrter
Feb 15, 1982·Cancer·D L PageM Landenberger
Sep 13, 1996·Science·Y WeiH A Chapman
Jan 1, 1997·Medical Hypotheses·M D Sternlicht, S H Barsky
Sep 11, 1998·BMJ : British Medical Journal·M J Silverstein
Jan 23, 1999·The American Journal of Pathology·F FendM Raffeld
Mar 16, 2001·Breast Cancer Research : BCR·S R Lakhani, M J O'Hare

❮ Previous
Next ❯

Citations

Apr 21, 2010·Expert Opinion on Investigational Drugs·Ralf HildenbrandPhilipp Stroebel
Jul 28, 2007·Reviews in Endocrine & Metabolic Disorders·Ann E VernonLewis A Chodosh
Feb 10, 2007·International Journal of Cancer. Journal International Du Cancer·Boye S NielsenKeld Danø
Oct 8, 2005·Advances in Anatomic Pathology·Sharon Nofech-MozesWedad Hanna
Feb 10, 2007·Expert Review of Anticancer Therapy·Tracey Irvine, Ian S Fentiman
Mar 16, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M Mimeault, S K Batra
Feb 20, 2008·Current Opinion in Genetics & Development·Min Hu, Kornelia Polyak

❮ Previous
Next ❯

Datasets Mentioned

BETA
X51675

Methods Mentioned

BETA
laser
PCR
antisense oligodeoxynucleotides
laser capture microdissection

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Related Papers

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Marcus LangenskiöldMarie-Louise Ivarsson
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
M D SternlichtS H Barsky
Journal of Mammary Gland Biology and Neoplasia
Sanford H Barsky, Nina J Karlin
© 2022 Meta ULC. All rights reserved