PMID: 8985323Jan 1, 1997Paper

Protein architecture of avian reovirus S1133 and identification of the cell attachment protein

Journal of Virology
J Martinez-CostasJ Benavente

Abstract

There are a number of discrepancies in the literature regarding the protein composition of the avian reoviruses. The present study demonstrates that avian reovirus S1133 contains at least 10 proteins (lambdaA, lambdaB, lambdaC, muA, muB, muBC, muBN, sigmaA, sigmaB, and sigmaC). Polypeptides muB, muBC, muBN, sigmaB, and sigmaC are components of the outer capsid layer of the virus, while lambdaA, lambdaB, muA, and sigmaA are core polypeptides. Protein lambdaC is a component of both layers, extending from the inner core to the outer capsid. The minor outer-capsid polypeptide sigmaC is shown to be the cell attachment protein, since it is the only viral polypeptide present in extracts of S1133-infected cells that binds specifically to chicken embryo fibroblasts; furthermore, its binding to avian cells was competitively inhibited by S1133 reovirions but not by mammalian reovirions. Our results also show that sigmaC is an oligomeric protein both in the virion and free in the cytoplasm, and preliminary results suggest that the multimer is made up of three monomeric units.

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Citations

May 8, 2018·Oncotarget·Manas R PraharajDeepak Kumar
Sep 9, 2005·Avian Pathology : Journal of the W.V.P.A·Erica SpackmanHolly Sellers
Jan 1, 2014·Uirusu·Takeshi Kobayashi
May 29, 2003·The Journal of General Virology·Claudia González-LópezJavier Benavente
May 5, 2007·Avian Pathology : Journal of the W.V.P.A·Hsin Y LinHung J Liu
Aug 5, 2009·Current Protocols in Microbiology·Anh TranKevin M Coombs
Mar 29, 2014·Avian Pathology : Journal of the W.V.P.A·Naresh JindalSagar M Goyal
Jun 15, 2010·Avian Pathology : Journal of the W.V.P.A·Dana GoldenbergJacob Pitcovski
Apr 11, 2006·Virus Genes·Yun ZhangGuangzhi Tong
Dec 26, 2013·Virus Genes·Liqiong TengMazhar I Khan
May 28, 2017·Virus Genes·Yuanyuan TianXing Ye
Aug 9, 2019·Avian Pathology : Journal of the W.V.P.A·Seyed Abed MirbagheriArash Ghalyanchilangeroudi
Dec 21, 2020·Transboundary and Emerging Diseases·Xiaoning JiangYouxiang Diao
Jul 7, 2018·Journal of Veterinary Research·Natalia Styś-FijołHanna Czekaj
Jun 19, 2002·Virology·Joseph HsiaoVikram N Vakharia
Oct 5, 2006·Virus Research·Javier Benavente, Jose Martínez-Costas
Aug 25, 2021·Avian Diseases·Masaji MaseHiroshi Iseki
Jan 8, 2013·Virology Journal·Ymene Hellal KortAbdeljelil Ghram

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