Protein arginine methyltransferase biology in humans during acute and chronic skeletal muscle plasticity

Journal of Applied Physiology
Tiffany L VanlieshoutVladimir Ljubicic

Abstract

Protein arginine methyltransferases (PRMTs) are a family of enzymes that catalyze the methylation of arginine residues on target proteins. While dysregulation of PRMTs has been documented in a number of the most prevalent diseases, our understanding of PRMT biology in human skeletal muscle is limited. This study served to address this knowledge gap by exploring PRMT expression and function in human skeletal muscle in vivo and characterizing PRMT biology in response to acute and chronic stimuli for muscle plasticity. Fourteen untrained, healthy men performed one session of sprint interval exercise (SIE) before completing four bouts of SIE per week for 6 wk as part of a sprint interval training (SIT) program. Throughout this time course, multiple muscle biopsies were collected. We found that at basal, resting conditions PRMT1, PRMT4, PRMT5, and PRMT7 were the most abundantly expressed PRMT mRNAs in human quadriceps muscle. Additionally, the broad subcellular distribution pattern of PRMTs suggests methyltransferase activity throughout human myofibers. A spectrum of PRMT-specific inductions, and decrements, in expression and activity were observed in response to acute and chronic cues for muscle plasticity. In conclusion, our findi...Continue Reading

References

Mar 14, 2000·The Journal of Biological Chemistry·J TangH R Herschman
May 21, 2003·Proceedings of the National Academy of Sciences of the United States of America·Neelu YadavMark T Bedford
Feb 17, 2005·Science's STKE : Signal Transduction Knowledge Environment·François-Michel BoisvertStéphane Richard
Jun 21, 2005·Genes & Development·Catherine TeyssierMichael R Stallcup
Oct 20, 2007·Science·Bingsheng ChangRichard K Bruick
Nov 1, 2007·Biochemical and Biophysical Research Communications·Hiroaki Iwasaki, Toshihiko Yada
Dec 15, 2007·Genes & Development·Dawin HyllusUta-Maria Bauer
Mar 26, 2008·Exercise and Sport Sciences Reviews·Martin J Gibala, Sean L McGee
Jan 20, 2009·Molecular Cell·Mark T Bedford, Steven G Clarke
Jan 24, 2009·Molecular Endocrinology·Young-Ho Lee, Michael R Stallcup
Aug 1, 2009·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Thomas B NicholsonStéphane Richard
Nov 10, 2009·The Journal of Biological Chemistry·Daehoon KimMark T Bedford
Nov 17, 2009·Biochemical and Biophysical Research Communications·Jungeun YuJaerang Rho
Mar 9, 2010·Analytical Biochemistry·Isabel Romero-CalvoFermín Sánchez de Medina
Jun 15, 2010·Biochimica Et Biophysica Acta·Chongtae KimGieun Kim
Sep 2, 2010·The Journal of Biological Chemistry·Kaoru Sakabe, Gerald W Hart
Apr 1, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jonathan P LittleMartin J Gibala
Sep 24, 2011·American Journal of Physiology. Cell Physiology·Vladimir LjubicicBernard J Jasmin
Mar 21, 2012·The Biochemical Journal·Shu-Ching Mary WangGeorge E O Muscat
Apr 4, 2012·Analytical Biochemistry·Andrew J GalpinScott Trappe
Apr 5, 2012·Nature Reviews. Genetics·Eric L Greer, Yang Shi
May 25, 2012·Expert Opinion on Therapeutic Targets·Boksik Cha, Eek-Hoon Jho
Feb 12, 2013·Cell Metabolism·Brendan Egan, Juleen R Zierath
Jun 12, 2013·Molecular Cell·Palaniraja ThandapaniStéphane Richard
Oct 17, 2013·Molecular & Cellular Proteomics : MCP·Ailan GuoMichael J Comb
Mar 5, 2015·Nature Communications·Yanzhong YangMark T Bedford
May 23, 2015·The Biochemical Journal·Angelika BöttgerAlexander Wolf
Jun 2, 2015·Nature Communications·Ting ZhangThomas Braun

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Citations

Oct 9, 2019·American Journal of Physiology. Endocrinology and Metabolism·Tiffany L vanLieshout, Vladimir Ljubicic
Nov 27, 2020·IScience·Derek W StouthVladimir Ljubicic

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Datasets Mentioned

BETA
GSE109657

Methods Mentioned

BETA
ubiquitination
transgenic
biopsy
biopsies
PCR
nuclear translocation

Key Resources (RRID) Mentioned

AB_310588
AB_420962
AB_310589
AB_10990266
AB_2801509
AB_2799401
AB_2665370
AB_2714013
AB_2801527
AB_306434

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