Protein arginylation of cytoskeletal proteins in the muscle: modifications modifying function

American Journal of Physiology. Cell Physiology
Dilson E Rassier, Anna Kashina

Abstract

The cytoskeleton drives many essential processes in normal physiology, and its impairments underlie many diseases, including skeletal myopathies, cancer, and heart failure, that broadly affect developed countries worldwide. Cytoskeleton regulation is a field of investigation of rapidly emerging global importance and a new venue for the development of potential therapies. This review overviews our present understanding of the posttranslational regulation of the muscle cytoskeleton through arginylation, a tRNA-dependent addition of arginine to proteins mediated by arginyltransferase 1. We focus largely on arginylation-dependent regulation of striated muscles, shown to play critical roles in facilitating muscle integrity, contractility, regulation, and strength.

References

Dec 7, 1971·Biochemistry·R W Lymn, E W Taylor
Oct 22, 1971·Nature·A F Huxley, R M Simmons
Aug 11, 1995·Journal of Molecular Biology·W LehmanR Craig
Dec 1, 1995·The Journal of Cell Biology·A HoumeidaJ Trinick
Feb 14, 1997·Journal of Molecular Biology·P VibertW Lehman
Sep 22, 1998·Journal of Muscle Research and Cell Motility·S V Perry
Apr 28, 2000·The Journal of Biological Chemistry·I V Davydov, A Varshavsky
Jul 6, 2002·Science·Yong Tae KwonAlexander Varshavsky
Mar 5, 1963·Biochemical and Biophysical Research Communications·A KAJIG D NOVELLI
Aug 28, 1959·Annals of the New York Academy of Sciences·H E HUXLEY, J HANSON
May 4, 2005·Molecular Cell·Mark T Bedford, Stéphane Richard
Jul 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Reena Rai, Anna Kashina
Oct 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Min Jae LeeYong Tae Kwon
Jun 24, 2006·Science·Marina KarakozovaAnna Kashina
Sep 28, 2007·PLoS Biology·Catherine C L WongAnna Kashina
May 15, 2008·The Journal of Physiological Sciences : JPS·Norio FukudaSatoshi Kurihara
Jul 31, 2008·Proceedings. Biological Sciences·Dilson E Rassier
Aug 28, 2009·American Journal of Physiology. Cell Physiology·Ivan PavlovDilson E Rassier
Nov 18, 2010·Biochemical and Biophysical Research Communications·Albert KalganovDilson E Rassier
Feb 2, 2011·The Review of Scientific Instruments·A LabudaD E Rassier
Jun 3, 2011·Protein Science : a Publication of the Protein Society·Alexander Varshavsky
Jul 26, 2011·Developmental Biology·Sougata Saha, Anna Kashina
Apr 25, 2012·Annual Review of Biochemistry·Takafumi TasakiYong Tae Kwon
May 26, 2012·Journal of Molecular and Cellular Cardiology·Satoshi KurosakaAnna Kashina
Jul 16, 2014·Cell Reports·Anabelle S CornachioneAnna Kashina
Aug 16, 2014·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Anna Kashina
Jun 23, 2015·Biochemical and Biophysical Research Communications·Fábio C MinozzoDilson E Rassier
Aug 20, 2015·Methods in Molecular Biology·Anna S Kashina
Sep 26, 2015·American Journal of Physiology. Cell Physiology·Anabelle S CornachioneDilson E Rassier
Oct 30, 2015·American Journal of Physiology. Cell Physiology·Felipe S LeiteDilson E Rassier
Apr 26, 2016·Exercise and Sport Sciences Reviews·Felipe de Souza LeiteDilson E Rassier
Dec 29, 2016·The Journal of Physiology·Nabil ShalabiDilson E Rassier

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Citations

Mar 7, 2019·American Journal of Physiology. Cell Physiology·Christopher G R Perry, Thomas J Hawke
Jan 5, 2021·Frontiers in Molecular Biosciences·Irem Avcilar-Kucukgoze, Anna Kashina
Jan 19, 2021·The Journal of Physiology·Ravi A KumarLeonardo F Ferreira

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Methods Mentioned

BETA
electron microscopy
force measurements
atomic force microscopy

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