Protein biomarker for psoriasis: A systematic review on their role in the pathomechanism, diagnosis, potential targets and treatment of psoriasis

International Journal of Biological Macromolecules
Krishna YadavManju Rawat Singh

Abstract

Psoriasis is defined as a long-lasting multifactorial inflammatory autoimmune skin condition precisely characterized by delimited, erythematic papules with adherent shiny scales. The conditions are led by hyperproliferative responses of epidermis due to hyperactivation and immature keratinocytes production. The psoriatic skin consists of the thickened epidermal layer, in concurrence with inflammatory exudates in the dermis mainly of dendritic cells, neutrophils, T cells, and macrophages, contributing to the distinct manifestation of psoriatic lesions. It consents to multifaceted and discrete pathology due to the genetic and immunological alteration resulting from abnormal expression of various regulatory and structural proteins. These proteins are associated with various cellular and sub-cellular activities. Therefore, the presence of protein in a pathological cellular environment in the psoriatic lesions as well as in serum could be a great avenue for the insight of pathomechanism, anticipation and diagnosis of psoriasis. Research of protein biomarker in psoriasis is yet a developing realm to be explored by both fundamental and clinical researchers. This review is an attempt to assimilate the current discoveries and revelation...Continue Reading

Citations

Sep 10, 2019·Redox Report : Communications in Free Radical Research·Fengli XuYongqiong Deng
Apr 4, 2019·Dermatologic Therapy·Giovanni DamianiUNKNOWN Young Dermatologists Italian Network
Jul 6, 2019·Mediators of Inflammation·Carmen Rodríguez-CerdeiraJosé Luís González-Cespón
Mar 9, 2019·International Journal of Molecular Sciences·Leena ChularojanamontriVisith Thongboonkerd
Dec 2, 2020·Journal of Clinical Nursing·Camila Fernandes PolloSilmara Meneguin
Jun 13, 2021·European Journal of Pharmacology·Krishna YadavManju Rawat Singh
Nov 4, 2021·Scientific Reports·Hannah KaiserPeter Riis Hansen

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