Protein biomarkers for the prediction of cardiovascular disease in type 2 diabetes

Diabetologia
Helen C LookerSUMMIT Investigators

Abstract

We selected the most informative protein biomarkers for the prediction of incident cardiovascular disease (CVD) in people with type 2 diabetes. In this nested case-control study we measured 42 candidate CVD biomarkers in 1,123 incident CVD cases and 1,187 controls with type 2 diabetes selected from five European centres. Combinations of biomarkers were selected using cross-validated logistic regression models. Model prediction was assessed using the area under the receiver operating characteristic curve (AUROC). Sixteen biomarkers showed univariate associations with incident CVD. The most predictive subset selected by forward selection methods contained six biomarkers: N-terminal pro-B-type natriuretic peptide (OR 1.69 per 1 SD, 95% CI 1.47, 1.95), high-sensitivity troponin T (OR 1.29, 95% CI 1.11, 1.51), IL-6 (OR 1.13, 95% CI 1.02, 1.25), IL-15 (OR 1.15, 95% CI 1.01, 1.31), apolipoprotein C-III (OR 0.79, 95% CI 0.70, 0.88) and soluble receptor for AGE (OR 0.84, 95% CI 0.76, 0.94). The prediction of CVD beyond clinical covariates improved from an AUROC of 0.66 to 0.72 (AUROC for Framingham Risk Score covariates 0.59). In addition to the biomarkers, the most important clinical covariates for improving prediction beyond the Frami...Continue Reading

References

Nov 29, 2001·Clinical Science·R J StevensUNKNOWN United Kingdom Prospective Diabetes Study (UKPDS) Group
May 30, 2003·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·G Roselli della RovereE Manzato
Oct 5, 2006·Journal of Lipid Research·Nicholas TentolourisNicholas Katsilambros
Jan 19, 2008·International Journal of Clinical Practice·D C ChanG F Watts
Jan 24, 2008·Circulation·Ralph B D'AgostinoWilliam B Kannel
Jul 2, 2008·Diabetes Care·Jan CederholmUNKNOWN Swedish National Diabetes Register
Dec 19, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Dominique P V de KleijnGerard Pasterkamp
Dec 25, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Sandrine CaronBart Staels
Feb 22, 2011·Journal of Internal Medicine·A MälarstigA Hamsten
Mar 15, 2011·The Breast : Official Journal of the European Society of Mastology·Eduardo CazapBenjamin O Anderson
Apr 1, 2011·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Andre Pascal KengneUNKNOWN ADVANCE Collaborative Group
Jul 19, 2011·International Journal of Cardiology·Allegra BattistoniMassimo Volpe
Jan 30, 2013·Lifetime Data Analysis·Aasthaa Bansal, Margaret Sullivan Pepe
May 15, 2013·Proteomics. Clinical Applications·Onno B BleijerveldDominique P V de Kleijn

❮ Previous
Next ❯

Citations

Sep 29, 2015·Trends in Endocrinology and Metabolism : TEM·Christian HerderMarc Y Donath
Jun 4, 2015·Biochimie·Marine Coué, Cedric Moro
Sep 11, 2016·Current Atherosclerosis Reports·Marja-Riitta Taskinen, Jan Borén
Apr 22, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Christian HerderBarbara Thorand
Jun 2, 2016·Journal of the American Heart Association·Joep van der LeeuwYvonne T van der Schouw
Sep 24, 2020·Journal of the American Heart Association·Marcus V B MalachiasMarc A Pfeffer
May 26, 2018·Diabetologia·Christoph NowakJohan Ärnlöv
Jun 26, 2018·Current Diabetes Reports·Rona J Strawbridge, Natalie R van Zuydam
Feb 9, 2018·Diabetes, Obesity & Metabolism·Maria P A BaldassarreTina Vilsbøll
Nov 19, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Gisele A AmaralFernanda R Giachini
Apr 24, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Rosaria Vincenza GiglioManfredi Rizzo
Mar 9, 2019·Open Medicine·Nebojsa KavaricAna Ninic

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.