Protein Biomarkers of Cardiovascular Disease and Mortality in the Community

Journal of the American Heart Association
Jennifer E HoDaniel Levy

Abstract

The discovery of novel and highly predictive biomarkers of cardiovascular disease (CVD) has the potential to improve risk-stratification methods and may be informative regarding biological pathways contributing to disease. We used a discovery proteomic platform that targeted high-value proteins for CVD to ascertain 85 circulating protein biomarkers in 3523 Framingham Heart Study participants (mean age, 62 years; 53% women). Using multivariable-adjusted Cox models to account for clinical variables, we found 8 biomarkers associated with incident atherosclerotic CVD, 18 with incident heart failure, 38 with all-cause mortality, and 35 with CVD death (false discovery rate, q<0.05 for all; P-value ranges, 9.8×10-34 to 3.6×10-2). Notably, a number of regulators of metabolic and adipocyte homeostasis were associated with cardiovascular events, including insulin-like growth factor 1 (IGF1), insulin-like growth factor binding protein 1 (IGFBP1), insulin-like growth factor binding protein 2 (IGFBP2), leptin, and adipsin. In a multimarker approach that accounted for clinical factors, growth differentiation factor 15 (GDF15) was associated with all outcomes. In addition, N-terminal pro-b-type natriuretic peptide, C-reactive protein, and lep...Continue Reading

References

Sep 1, 1979·American Journal of Epidemiology·W B KannelW P Castelli
Dec 23, 1971·The New England Journal of Medicine·P A McKeeW B Kannel
Sep 15, 1999·Journal of Immunological Methods·R T Carson, D A Vignali
Oct 12, 2000·Regulatory Peptides·C M SteppanA G Swick
Mar 9, 2002·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·A Raynaud-SimonY Le Bouc
Mar 26, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Stephen J Nicholls, Stanley L Hazen
May 20, 2005·The New England Journal of Medicine·Michael G ShlipakCatherine Stehman-Breen
Sep 5, 2006·The American Journal of Cardiology·W H Wilson TangStanley L Hazen
Dec 22, 2006·The New England Journal of Medicine·Thomas J WangRamachandran S Vasan
Feb 28, 2009·Journal of the American College of Cardiology·David S FrankelJames B Meigs
Mar 27, 2009·Atherosclerosis·Yoji KojimaMakoto Tanaka
Jun 30, 2009·Journal of the American Geriatrics Society·Donglei HuUNKNOWN Health, Aging, and Body Composition Study
Jul 2, 2009·JAMA : the Journal of the American Medical Association·Olle MelanderThomas J Wang
Apr 10, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Carolyn S P LamRamachandran S Vasan
Jan 5, 2011·Statistics in Medicine·Michael J PencinaEwout W Steyerberg
Nov 20, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Alex P ReinerRussell P Tracy
Mar 23, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Meredith C FosterUNKNOWN CKD Biomarkers Consortium
Sep 17, 2013·Trends in Endocrinology and Metabolism : TEM·Andrew D NguyenRobert V Farese
Nov 26, 2013·Lancet·Paul M Ridker, Nancy R Cook
Jul 6, 2014·Cell·James C LoBruce M Spiegelman
Dec 19, 2014·Circulation·Dariush MozaffarianUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Mar 8, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Meredith C FosterUNKNOWN CKD Biomarker Consortium and the CRIC Study Investigators
Jun 22, 2016·JAMA : the Journal of the American Medical Association·Peter GanzStephen A Williams

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Citations

Dec 26, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Ravi V ShahJane E Freedman
Jan 10, 2019·Hypertension·Joshua A KeefeDaniel Levy
May 8, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·João Pedro FerreiraUNKNOWN FIBRO-TARGETS investigators
Jul 31, 2019·Expert Review of Proteomics·Tamara TominRuth Birner-Gruenberger
Aug 3, 2019·Annals of Clinical and Translational Neurology·Emer R McGrathSudha Seshadri
Oct 3, 2019·Current Opinion in Lipidology·Natalie Arnold, Wolfgang Koenig
Jan 28, 2020·Annual Review of Medicine·Usman A Tahir, Robert E Gerszten
Jan 30, 2020·Circulation·Salim S ViraniUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Mar 12, 2020·Journal of the American Heart Association·Nels C OlsonMary Cushman
Jun 25, 2020·Journal of the American Heart Association·Sri Lekha TummalapalliUNKNOWN CRIC Study Investigators †
Jun 27, 2020·Annals of Clinical and Translational Neurology·José Rafael RomeroSudha Seshadri
Aug 13, 2020·Circulation Research·Dong Heon LeeAndrew D Johnson
Aug 19, 2020·European Heart Journal·Renate M HoogeveenErik S G Stroes
Sep 15, 2020·Journal of the American Heart Association·Emer R McGrathSudha Seshadri
Aug 23, 2019·Journal of the American Heart Association·Eva Warensjö LemmingKarl Michaëlsson
Jan 17, 2020·Circulation. Arrhythmia and Electrophysiology·Laila StaerkLudovic Trinquart
Apr 29, 2020·Vascular Health and Risk Management·Rahul VasudevMahesh Bikkina
Jun 20, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Marc-André NolinFrédéric Picard
Jun 30, 2019·Journal of Clinical Medicine·Daniel DalosMichael Sponder
Jul 31, 2020·Nutrients·Hyeon-Jeong LeeHyun-Jin Kim
May 12, 2019·Critical Reviews in Clinical Laboratory Sciences·Stéphanie DesmedtMarijn M Speeckaert
Nov 22, 2019·Frontiers in Molecular Biosciences·Kuldeep DhamaSunil Kumar Joshi
Jan 5, 2021·Current Atherosclerosis Reports·Lale Tokgozoglu, Duygu Kocyigit
Dec 4, 2020·International Journal of Molecular Sciences·Mirthe DekkerDominique P V de Kleijn
Feb 11, 2021·Arquivos brasileiros de cardiologia·Bruna Miers MayLuis Eduardo Rohde
Jan 28, 2021·Circulation·Salim S ViraniUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
May 30, 2020·Trends in Molecular Medicine·Christian SchulteManuel Mayr

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Methods Mentioned

BETA
ELISA
Assay

Software Mentioned

SAS

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