Protein-bound polysaccharide K partially prevents apoptosis of circulating T cells induced by anti-cancer drug S-1 in patients with gastric cancer

Oncology
Koji KonoHideki Fujii

Abstract

It has been shown that T-cell dysfunction, including apoptosis of peripheral blood T cells, commonly occurs in patients receiving chemotherapy. In order to evaluate whether concomitant administration of the oral biological response modifier protein-bound polysaccharide K (PSK) could induce anti-apoptotic effects in patients treated with the anti-cancer drug, S-1, peripheral blood T cells were analyzed for induction of apoptosis, caspase-3 activities and expression of proapoptotic protein Bax and anti-apoptotic protein Bcl-2 in patients with curatively resected stage III gastric cancer, who were randomly assigned to postoperative adjuvant therapy with S-1 alone (n = 10) or S-1 combined with PSK (n = 10). T-cell apoptosis 5 weeks after adjuvant therapy was significantly higher in the S-1 group (24.1 +/- 5.0%) than in the S-1 + PSK group (19.1 +/- 3.9%). S-1 induced T-cell apoptosis and concomitantly elevated caspase-3 activities and Bax expression in peripheral blood T cells. In addition, PSK partially prevented the T-cell apoptosis induced by S-1. PSK could partially prevent the T-cell apoptosis induced by S-1.

Citations

Nov 26, 2009·American Journal of Respiratory Cell and Molecular Biology·Po-Len LiuInn-Wen Chong
Sep 5, 2012·Carbohydrate Polymers·Aizhen ZongFengshan Wang

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