Protein-Bound Uremic Toxin Profiling as a Tool to Optimize Hemodialysis

PloS One
S ElootR Vanholder

Abstract

We studied various hemodialysis strategies for the removal of protein-bound solutes, which are associated with cardiovascular damage. This study included 10 patients on standard (3 x 4 h/week) high-flux hemodialysis. Blood was collected at the dialyzer inlet and outlet at several time points during a midweek session. Total and free concentration of several protein-bound solutes was determined as well as urea concentration. Per solute, a two-compartment kinetic model was fitted to the measured concentrations, estimating plasmatic volume (V1), total distribution volume (V tot) and intercompartment clearance (K21). This calibrated model was then used to calculate which hemodialysis strategy offers optimal removal. Our own in vivo data, with the strategy variables entered into the mathematical simulations, was then validated against independent data from two other clinical studies. Dialyzer clearance K, V1 and V tot correlated inversely with percentage of protein binding. All Ks were different from each other. Of all protein-bound solutes, K21 was 2.7-5.3 times lower than that of urea. Longer and/or more frequent dialysis that processed the same amount of blood per week as standard 3 x 4 h dialysis at 300 mL/min blood flow showed n...Continue Reading

References

May 1, 1991·Kidney International·R A OdellK Schindhelm
Aug 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J T Daugirdas
Dec 23, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G LesafferR Vanholder
Feb 7, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R Ouseph, R A Ward
Aug 8, 2001·Seminars in Dialysis·D Schneditz, J T Daugirdas
Feb 19, 2002·Kidney International·Elaine M SpaldingKen Farrington
Jun 21, 2002·The International Journal of Artificial Organs·S StillerH Mann
Jul 31, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Riccardo Maria FagugliRaymond Vanholder
Apr 5, 2003·Kidney International·Raymond VanholderUNKNOWN European Uremic Toxin Work Group (EUTox)
Jun 24, 2004·Journal of the American Society of Nephrology : JASN·Timothy W MeyerThomas H Hostetter
May 7, 2005·Contributions to Nephrology·Bert Bammens, Pieter Evenepoel
Jul 15, 2005·Kidney International·Timothy W MeyerThomas H Hostetter
Mar 28, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gerald SchulmanNelson Kopyt
Apr 14, 2006·Journal of the American Society of Nephrology : JASN·Carmine ZoccaliFrancesco Perticone
Apr 14, 2006·Kidney International·H YamamotoE Kusano
Oct 17, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Eva SchepersRaymond Vanholder
Jul 31, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sunny ElootRaymond Vanholder
Dec 25, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rosemary OusephRichard A Ward
Dec 28, 2007·Kidney International·S ElootR Vanholder
Feb 22, 2008·Journal of the American Society of Nephrology : JASN·Raymond VanholderUNKNOWN European Uremic Toxin Work Group
Feb 29, 2008·Kidney International·B K I MeijersP Evenepoel
Mar 13, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ayinuer AdijiangToshimitsu Niwa
Sep 24, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Natalie MeertRaymond Vanholder
Feb 20, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sunny ElootRaymond Vanholder
Jul 21, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Björn K I MeijersPieter Evenepoel
Aug 22, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Fellype C BarretoUNKNOWN European Uremic Toxin Work Group (EUTox)
Sep 17, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Detlef H KrieterBernard Canaud
Nov 17, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sophie LiabeufUNKNOWN European Uraemic Toxin Work Group (EUTox)
Aug 27, 2010·Science Translational Medicine·Harald MischakAntonia Vlahou
Sep 4, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Carlo BasileCarlo Lomonte
Nov 26, 2010·The New England Journal of Medicine·Glenn M ChertowAlan S Kliger
Feb 12, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Natalie MeertRaymond Vanholder
Jun 21, 2011·Seminars in Dialysis·Noémie Jourde-ChichePhilippe Brunet
Sep 21, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Francisco MaduellJosep M Campistol
Oct 29, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Baris U AgarJohn K Leypoldt
Dec 15, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Natalie MeertRaymond Vanholder
Jan 11, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tammy L SirichTimothy W Meyer
Aug 28, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sunny ElootRaymond Vanholder
Apr 5, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Tom CornelisJeroen P Kooman

❮ Previous
Next ❯

Citations

May 18, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Orlando CamachoTammy L Sirich
Sep 6, 2017·Scientific Reports·Vaibhav MaheshwariPeter Kotanko
Nov 2, 2016·Journal of the American Society of Nephrology : JASN·Björn Meijers, Raymond Vanholder
Mar 21, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Jeffrey PerlUNKNOWN American Society of Nephrology Dialysis Advisory Group
Feb 8, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Wim Van Biesen, Sunny Eloot
Oct 12, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·John K LeypoldtBernd Krause
Jul 31, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Evelien SnauwaertSunny Eloot
Aug 24, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Joshua David KingBernard G Jaar
Jul 4, 2019·Toxins·Olivier DeltombeSunny Eloot
Aug 20, 2019·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Kai LauriIvo Fridolin
Aug 22, 2020·The International Journal of Artificial Organs·Celine De VosSunny Eloot
Oct 25, 2016·Seminars in Dialysis·Frank J O'BrienTimothy W Meyer
May 31, 2017·Seminars in Dialysis·Tammy L Sirich
May 8, 2018·Nature Reviews. Nephrology·Claudio Ronco, William R Clark
Jun 25, 2016·The International Journal of Artificial Organs·Giustina CasagrandeMaria Laura Costantino
Dec 6, 2016·Toxins·Sheldon C Leong, Tammy L Sirich
Sep 7, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Mónica Faria, Maria Norberta de Pinho
Mar 25, 2021·Nature Reviews. Nephrology·Jonathan D RavidVipul C Chitalia
Sep 29, 2020·The Veterinary Clinics of North America. Small Animal Practice·J D Foster
Jan 17, 2017·Kidney International·Tammy L SirichUNKNOWN Frequent Hemodialysis Network (FHN) Trial Group
Jul 14, 2021·International Urology and Nephrology·Jessyca Sousa de BritoDenise Mafra

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Frank Y LuoTimothy W Meyer
American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
John K LeypoldtR B Deeter
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Tammy L SirichTimothy W Meyer
© 2022 Meta ULC. All rights reserved