Protein C activators from snake venoms and their diagnostic use

Haemostasis
P M Gempeler-MessinaC Müller

Abstract

Proteinases converting the zymogen protein C (PC) of vertebrates into activated PC have been detected in several snake venoms. Most PC activators have been purified from venom of snake species belonging to the genera of the Agkistrodon complex. Unlike the physiological, thrombin-catalyzed PC activation reaction which requires thrombomodulin as a cofactor, most snake venom activators directly convert the zymogen PC into the catalytically active form which can easily be determined by means of coagulation or chromogenic substrate techniques. Due to this feature, the fast-acting PC activator Protac from Agkistrodon contortrix contortrix (southern copperhead snake) venom has found a broad application in diagnostic practice for the determination of disorders in the PC pathway. Recently, screening assays for the PC pathway have been introduced, based on the observation that the PC pathway is probably the most important physiological barrier against thrombosis.

Citations

Jun 7, 2014·Toxicon : Official Journal of the International Society on Toxinology·Gil HadarItamar Aroch
May 19, 2006·Pathophysiology of Haemostasis and Thrombosis·R Manjunatha Kini
Aug 17, 2005·Journal of Thrombosis and Haemostasis : JTH·Q LuK J Clemetson
Feb 11, 2012·International Journal of Laboratory Hematology·P C CooperR M Maclean
Aug 4, 2011·Journal of Thrombosis and Haemostasis : JTH·R M Kini
Apr 8, 2011·The FEBS Journal·Tse Siang KangR Manjunatha Kini
Jun 1, 2005·Toxicon : Official Journal of the International Society on Toxinology·Neville Marsh, Vaughan Williams
Mar 7, 2013·Toxicon : Official Journal of the International Society on Toxinology·Ying ZhengWen-Hui Lee
Jan 19, 2010·Matrix Biology : Journal of the International Society for Matrix Biology·Johannes A Eble
May 5, 2017·The Journal of Biological Chemistry·Rachid EssalmaniNabil G Seidah
Sep 29, 2019·Toxins·Tarek Mohamed Abd El-AzizJames D Stockand
Jul 13, 2006·The Biochemical Journal·R Manjunatha Kini
Jan 6, 2005·The Journal of Biological Chemistry·Zhongliang ZhuLiwen Niu

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